Histopathological Pattern of Central Nervous System Tumors:A 5-Year Retrospective Study, at a Tertiary Hospital in Ethiopia.
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Date
2019-10
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Addis Ababa University
Abstract
Introduction: Central nervous system tumors are a heterogeneous group of neoplasms, they differ not only in their histomorphological features but also have a distinct biological background and disease course. CNS tumors are confined to the brain, spinal cord, meninges, cranial and Para spinal nerves, with each tumor having its own features, location, morphology, prognosis and treatment.
Objective:The purpose of this study is to provide the histopathological pattern of CNS tumors in a tertiary care center in Ethiopia.
Material and method: A retrospective descriptive histopathological analysis of central nervous system tumors carried out in the Postgraduate Department of Pathology in Tikur Anbessa Specialized Referral Hospital (TAH), Addis Ababa, Ethiopia. Patients data were retrieved from the archives of the department of Pathology for a period of 5 years from January 01, 2015 to August 31, 2019.
Result:A total of 565 cases were analyzed and a wide range of histopathological diagnosis of CNS tumors was observed. Patients ages ranged from 2minths-80 years with a mean age of 36.9 years and a male to female ratio of 1:1.11. Majority of tumors had intracranial location (499 cases, 88.3%).Most of CNS tumors were low grade belonged to Grade I 70% followed by grade II 14. 8%. Tumors of meningeal tissue were most common 51.9% followed by neuroepithelial 24.2 %. When examining the data pertaining to specific types of tumors, most frequent type of CNS tumors was meningioma(272 cases, 48.1%) followed by astrocytoma (86 cases, 15.2%)
Conclusion: The present study thus reflects the histopathological patterns of CNS tumors from our center. Although there is availability of advanced imaging techniques at present, still histopathological examination is gold standard in their diagnosis.The conventional H & E staining is the mainstay for pathologic diagnosis, and IHC also plays a major role in differential diagnosis and improving diagnostic accuracy.
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CNS Tumors, Meningioma, Astrocytoma& Histopathology