Investigation of Antimicrobial Activities of Albizia Gummifera and Ferula Communis on Streptococcus Pneumoniae and Streptococcus Pyogenes Causing Upper Respiratory Tract Infections In Children

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A study involving the collection and isolation of the common Gram-positive bacterial pathogens and the antimicrobial susceptibility test of traditionally used plant species was conducted over a period of 5 months (January – August, 2004) at the Ethiopian Health, and Nutrition research institute. Among the specimens collected from the patients of URTIs visiting the OPD of Black Lion hospital, Kirkos and Tekle Haimonot Health centers, a total of 191 infants and children (aged< 14 Years) were included as subjects of the study of which 60 specimens of ear discharge were collected from those with clinically symptomatic for acute otitis media and 131 specimens of throat swab were from those with confirmed pharyngotonsillitis clinical symptoms. Out of the total 191 specimens collected, 12% (22 to 191) were positive for clinical isolates of S. Pyogenes ((3.3% (2 of 60) from the specimens of ear discharge, and 15% (20 of 131) from the throat swabs)). Among 60 specimens, of ear discharge collected from the patients of AOM, 10% (6 of 60) of the sample were found positive for S. Peneumonia isolates. The in vitro antibacterial activites of 80% methanol crude extracts prepared from the seeds of Ablizia gummifera and, roots of Ferula communis as well as their respective hydroalcoholic solvent fractionates of both plant species were tested for inhibitory activity against the clinical isolates of six S. pneumonae and twenty two S. pyogenes using agar dilution method. 80% ethanol solublized fractions of both plants were found to have antibacterial effects to all assayed bacteria while aqueous solublized fractions did not exhibit any effect. Minimum inhibitory concentration (MIC of the 80% ethanol solubilized fractions was determined and the MIC of the fractions ranged from 500μg/ml t to 1000μg/ml for both plants showing the extracts may contain bioactive compounds of the therapeutic interest