Wound Healing and Anti-Inflammatory Activities of Leaf Gel of Aloe trigonantha L.C. Leach in Rats

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Addis Abeba University


Aloe trigonantha L.C. Leach, which locally called ‘Eret’ (Amharic), is among endemic Aloe species of Ethiopia. Traditionally its leaf is used for the treatment of different ailments including wound and infectious as well as inflammatory diseases. However, there was no in vivo studies which prove its claimed use for wound healing and anti-inflammatory activity. Therefore, the present study was aimed at evaluating the in-vivo wound healing and anti-inflammatory effects of the leaf gel of the plant in rats. The leaf gel powder of the plant was prepared after drying the gel in lyophilizer. It was studied for wound healing activity topically by incorporating in simple ointment base in concentration of 5% (w/w) and 10% (w/w). Excision and incision models were used for wound healing activity in rats. Parameters including wound contraction and period of epithelialization were studied in case of the excision wound model, while wound tensile strength was evaluated using incision wound model. Xylene induced ear edema model and cotton pellet induced granuloma model were used for anti-inflammatory study. The leaf gel powder of A. trigonantha was given orally at dose of 100, 200 and 400 mg/kg in both models of antiinflammatory studies. An anti-inflammatory effect was measured by reduction of ear edema weight and reduction of wet exudate and dry granuloma weight in both of xylene induced ear edema and cotton pellet induced granuloma models respectively. Treatment of wound with ointment containing 5% and 10% (w/w) of the gel exhibited significantly increased wound contraction rate, shorter epithelialization time, higher skin breaking strength (p < 0.05) compared to control. A. trigonantha leaf gel powder also produced dose-dependent significant reductions (p < 0.05) of inflammation compared to control in both models. Therefore, results of the current study demonstrated that A. trigonantha is a potential wound-healing and anti-inflammatory agent in rat models of wound and inflammation which provides evidence for the traditional claim



Aloe trigonantha, wound healing, anti-inflammatory, granuloma model, ear edema model