Sero-Prevalence of HBV and HCV Among Chronic Liver Disease Patients Visiting OPD in Public Hospitals in Addis Ababa, Ethiopia
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Date
2011-05
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Addis Ababa University
Abstract
Background: Hepatitis B and C viruses (HBV & HCV) are hepatotropic viruses causing viral hepatitis, chronic liver disease and hepatocellular carcinoma. Hepatitis B and C virus infections are still major public health problems around the globe. Both of these viruses are transmitted mainly through the parenteral route and therefore a dual infection of these viruses can occur and even persists in the same patient. They are prevalent in different parts of the world including Ethiopia. In view of this, the present study was designed to determine the prevalence of HBV and HCV infection and co-infection in clinically diagnosed chronic liver disease patients who visited public hospitals of Addis Ababa.
Objective: The objective of this study was to determine the prevalence of HBV and HCV infection among chronic liver disease patients who visited public hospitals of Addis Ababa, Ethiopia.
Method: Hospital based cross-sectional study was conducted in three public hospitals of Addis Ababa over a period of 7 months (Nov 2010- May 2011) on clinically diagnosed chronic liver disease patients. By using questionnaire brief history and risk factors were taken from each volunteering patient. Serum samples from each volunteering patients was screened for the presence of HBsAg and anti-HCV Ab by using qualitative rapid test kits.
Result: A total of 120 participants who have chronic liver disease participated in the study, where 76 of them were males and the remaining 44 were females. The age distribution range form 18-80 years and the mean age was 40.99 years ±14 SD. The overall prevalence of HBsAg and HCV was 35.8% and 22.5% respectively. The prevalence of HBsAg and anti-HCV Ab was high in age below 50 years. 2.5% of the study participants had combined HBV/HCV infection which is possible because of their common modes of transmission.
Conclusion: The prevalence of HBV and HCV in chronic liver disease patients is high and dental extraction at health facility was statistically associated with HCV infection.
Key words: Hepatitis B virus, Hepatitis C virus, chronic liver disease, prevalence, co-infection
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Keywords
Hepatitis B virus, Hepatitis C virus, Chronic liver disease, Prevalence