Prevalence of Bacterial Vaginosis Among Pregnant Women Attending Antenatal Care in Tikur Anbessa University Hospital, Addis Ababa, Ethiopia.

dc.contributor.advisorDr. Woldeamanuel, Yimtubezinash,Associate professor(MD, M. Sc, PhD)
dc.contributor.advisorDr. Asrat, Daniel,Associate professor (MD, M. Sc, PhD)
dc.contributor.authorMengistie, Zemenu
dc.date.accessioned2021-07-19T06:53:43Z
dc.date.accessioned2023-11-05T09:35:47Z
dc.date.available2021-07-19T06:53:43Z
dc.date.available2023-11-05T09:35:47Z
dc.date.issued2012-06
dc.description.abstractBackground: Bacterial vaginosis is one of the most common genital tract infections among reproductive age group. It is associated with different gynecologic and poor obstetric out come. The prevalence of bacterial vaginosis varies from country to country even in the same country it varies at population of interest. Different social and sexual factors can contribute for development of bacterial vaginosis. Bacterial vaginosis can be easily diagnosed by combination of two Amsel’s criteria. Objectives: This study was undertaken to determine the prevalence of bacterial vaginosis and to evaluate the accuracy of Amsel’s criteria individually or in combination of two for the clinical diagnosis of bacterial vaginosis among pregnant women attending Antenatal care in Tikur Anbessa University Hospital, Addis Ababa, Ethiopia. An attempt has also been made to identify the possible risk factors associated with bacterial vaginosis. Methods: In this observational study during the period from November 2011 to April 2012, 252 pregnant women were screened for bacterial vaginosis in Tikur Anbessa University Hospital. Vaginal swabs were collected for pH determination, saline wet mount microscopic examination to detect clue cells, KOH preparation for whiff test and Gram-stain evaluation of vaginal flora for diagnosis of bacterial vaginosis by Nugent scoring system. Accuracy of clinical diagnosis using individual and two of Amsel’s criteria was evaluated. Results: The prevalence of bacterial vaginosis was 18.3% by Amsel’s two of three criteria and 19.4% using Gram stain Nugent scoring system. The prevalence of bacterial vaginosis was 31.6% and 15.9% among symptomatic and asymptomatic pregnant women respectively. A high percentage of bacterial vaginosis positive pregnant women were asymptomatic (63.3%) whereas the remaining 36.7% bacterial vaginosis positive pregnant women were complaining abnormal vaginal discharge with or without unpleasant smell. Comparing with Gram stain Nugent scoring methods the clinical diagnosis by Amsel’s criteria had sensitivity of 85.7%, specificity of 98%, and positive predictive value of 91.3% and negative predictive value of 96.6%. The most sensitive and specific individual criterion was clue cells and with highest positive and negative predictive value. Amsel’s criteria with the lowest sensitivity and specificity were whiff test and vaginal pH respectively. Combination of clue cells with vaginal pH test were the highest in sensitive while whiff test with clue cells were the highest in specificity than the other combined two Amsel’s criteria. After adjusted for other factors multiple life time sexual partner (OR: 8.6; 95% CI: 2.5, 29) and previous history of spontaneous abortion (OR: 5.9; 95% CI: 1.5, 23) had remained significantly associated with prevalence of bacterial vaginosis. They were the most likely to be a risk factors for bacterial vaginosis infection. Conclusion and Recommendation: The prevalence of bacterial vaginosis among pregnant women was higher in asymptomatic pregnant women and associated with the factors multiple lifetime sexual partner and previous spontaneous abortion. Amsel’s criteria diagnosis of bacterial vaginosis can be simplified using a combination of the two criteria, vaginal pH and clue cells, in settings where time or Gram staining is not available. So using these simplified diagnostic criteria is better to screen pregnant women as a routine activityduring antenatal care.en_US
dc.identifier.urihttp://etd.aau.edu.et/handle/123456789/27246
dc.language.isoen_USen_US
dc.publisherAddis Ababa Universityen_US
dc.subjectBacterial vaginosis, Pregnancy, Amsel’s criteria, Nugent Scoring System,Ethiopiaen_US
dc.titlePrevalence of Bacterial Vaginosis Among Pregnant Women Attending Antenatal Care in Tikur Anbessa University Hospital, Addis Ababa, Ethiopia.en_US
dc.typeThesisen_US

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