Patterns of treatment outcome of epilepsy and associated factors among patients on followup at adult neurology clinic at Tikur Anbessa Specialized Teaching Hospital: Hospital based cross sectional study October 1-30, 2020G.C
| dc.contributor.advisor | Amare, Amanuel(MD, Internisit, Associate professor of neurology) | |
| dc.contributor.advisor | Gelan, Yohannes Debebe(MD, Assistant professor of neurology) | |
| dc.contributor.advisor | Gebrewold, Meron Awrarisold (MD, Assistant professor of neurology) | |
| dc.contributor.author | Dagnachew, Hilina | |
| dc.date.accessioned | 2021-03-14T08:11:49Z | |
| dc.date.accessioned | 2025-01-08T14:37:11Z | |
| dc.date.available | 2021-03-14T08:11:49Z | |
| dc.date.available | 2025-01-08T14:37:11Z | |
| dc.date.issued | 2020-12 | |
| dc.description.abstract | Background: Pattern of treatment outcome can be categorized based on the effect of an intervention on seizure control in relation to occurrence of adverse effects. A minimum of 12 months of seizure freedom from all types of seizure is required to label a treatment outcome as seizure freedom. Predictors of seizure treatment outcome can be utilized to direct resources towards strategies that lead to good seizure outcome. Despite the availability of interventions which can control the seizure frequency to an extent of 70% a large number of epileptic patients continue to have a seizure. Objective: Patterns of treatment outcome of epilepsy and associated factors among patients on follow-up at adult neurology clinic at Tikur Anbessa Specialized Teaching Hospital: Hospitalbased cross-sectional study October 1-30, 2020G.C Methods: A hospital-based cross-sectional descriptive study is conducted among epileptic patients who have a follow-up at the Neurology department referral clinic, Tikur Anbessa Specialized Hospital, Addis Ababa from Oct 1-30. A convenient sampling method was used. A questionnaire including, sociodemographic status, is used to assess patterns of treatment outcome with associated factors. The data were entered, processed, and analyzed using SPSS 26 window version. Result: A total of 245 participants were included in the study. More than half 145(59.2%) of patients with epilepsy were in the age range of 15-30. Among participants male gender account for 113(54.3%) and female gender for 112(45.7%). The age of onset of a seizure was below 15 for 115(46.9%) of patients. Generalized onset seizures 154(62.9%) was the commonest type of seizure diagnosed. Comorbidity is seen in 110(44.9%). Monotherapy 68(27.8%) was commonly used for treatment of seizure. The 166(67.8%) of patients had developed antiepilepatic related adverse event. Antiepileptic dugs non adherence seen in 68(27.8%)of patients. In 41(16.7%) of patients there is no seizure attack after initiation of antiepileptic medications. Seizure freedom was seen in 99(40.4%) of patients. Sex (adjusted odds ratio (AOR)= 3.316, CI=1.044-10.534;p-value=0.042) was predictor of poor seizure control. Conclusion: In this study, it was found that more than two-thirds of the participants continue to have seizure activity despite being placed on antiepileptic medications. Still, a large proportion of patients are not adherent to the medication prescribed. The older generation of antiepileptic medications utilized and more than half of patients reporting adverse events. Male sex is found to have a three times higher risk of developing poor seizure control. A further multicenter study of different subgroups of treatment is recommended and effect of sex on seizure can be studied further. | en_US |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/25466 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Pattern of treatment response, Anti-epileptic drugs, Adverse Events | en_US |
| dc.title | Patterns of treatment outcome of epilepsy and associated factors among patients on followup at adult neurology clinic at Tikur Anbessa Specialized Teaching Hospital: Hospital based cross sectional study October 1-30, 2020G.C | en_US |
| dc.type | Thesis | en_US |