Comparative Study Between Dpp-4 Inhibitors Based Therapies and other Non-Insulin Based Therapies Among Type 2 Diabetes Patients in Addis Ababa, Ethiopia
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Date
2016-05
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Addis Ababa University
Abstract
Background: Type-2 diabetes mellitus is characterized by hyperglycemia as a result of
defects in insulin secretion or insulin action. Over the years, attempts to regulate diabetics
therapeutically through glycemic control have reduced complications and trauma
associated with the disease.
Objective: The aim of the present study was to compare the effect of DPP-4 inhibitors
based therapies and non-insulin based therapies among type-2 diabetic patients attending
diabetic clinics at Tikur Anbessa Specialized Hospital, and Huleshet Higher Private Clinic,
Addis Ababa, Ethiopia.
Methods: Hospital based cross-sectional study was conducted between the two types of
treatment strategies among type-2 diabetic patients. Sixty type-2 diabetic patients were
randomly selected from patients attending diabetic clinic at Tikur Anbessa Specialized
Hospital, who were receiving non-insulin based therapies and 30 type-2 diabetic patients
who were receiving DPP-4 inhibitors based therapies from Huleshet Higher Private clinic
were included in this study.
Results: The mean total cholesterol (TC), triglyceride (TG), low density lipoprotein
(LDL), serum urea and serum creatinine were significantly lower in type-2 diabetic
patients who received DPP-4 inhibitors based therapies than non-insulin based treated
type-2 diabetic patients. The mean value of high density lipoprotein (HDL) was also
significantly higher as compared to type-2 diabetic patients who were receiving non-insulin
based therapies. The mean value of body mass index (BMI) and fasting blood sugar
(FBS) were lower in the DPP-4 inhibitors based therapies as compared to non-insulin
based treated type-2 diabetic patients but statistically not significant (p>0.05). Among
diabetic patients, females had higher level of FBS, TG, LDL, serum urea, BMI and lower
level of TC, HDL and serum creatinine as compared to males in both groups. However, the
differences were not statistically significant (p>0.05).
Conclusion: The DPP-4 inhibitors based therapy helps in normalizing lipid profiles, FBS
and also better adjustments in kidney clearance pattern. It also as a result helps in adjusting
the weight to height ratios and helps to maintain BMI in the normal range.
Keywords: Type-2 diabetes, DPP-4, Lipid profile, Renal function test, Incretin-based
therapy, Body mass index.
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Keywords
Type-2 diabetes; DPP-4; Lipid profile; Renal function test; Incretin-based therapy; Body mass index