Assessment of Drug Therapy Problems and Contributing Factors among Ambulatory Patient with Type 2 Diabetes mellitus in Dagmawi Menelik Hospital, Addis Ababa, Ethiopia
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Date
2021-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Patients with diabetes are at high risk of drug therapy-associated problems (DTPs), as they are
exposed to multiple medications. Studies conducted on DTPs in diabetic patients in Ethiopia are,
however, limited. This study was, therefore, aimed to assess the magnitude, pattern, and factors
associated with DTPs among patients with type 2 diabetes at Dagimawi Menelik Hospital
(DMH). A cross-sectional study was conducted among 294 patients who fulfilled the inclusion
criteria. Patients were interviewed using a structured data collection format, involving
retrospective medical chart review. DTPs were assessed using Cipolle‘s classification system.
Descriptive data were reported using tables and figures. A multivariate logistic regression
analysis was performed to identify factors associated with DTPs. A total of 448 DTPs in 193
(65.6%) patients were identified. Most commonly identified DTPs were non-compliance,
118(26.3%), need additional drug, 110(24.6%), and dosage too low 89 (19.9%). On multivariate
analysis, history of hospitalization (AOR= 4.34, 95% CI: 1.21, 15.54), poor glycaemic control
(AOR= 59.5 95% CI: 18.9, 188.0), presence of co-morbidity (AOR= 6.7, 95% CI: 2.4, 19.0) and
diabetes complication (AOR= 4.1, 95% CI: 1.1, 15.2) were positively associated with occurrence
of DTP On the other hand, physical activity (AOR= 0.2, 95% CI: 0.0, 0.7), absence of polypharmacy
(≤3
drugs)
(AOR=
0.1,
95%
CI:
0.0,
0.6)
were
protective
for
the
development
of
DTP.
In
conclusion,
there
was
high
prevalence
of
DTP
particularly
among
patients
with
poor
glycemic
control,
history of hospitalization, comorbidities, complications, inactivity and polypharmacy..
Further studies on the prevention and management of DTPs, therefore, need to be conducted.
Description
Keywords
Diabetes mellitus, drug therapy problems, factors, Ethiopia