Histopathological Characteristics and Immunoh is to Chemical Biomarkers of Invasive Breast Cancer in Ethiopia Women
| dc.contributor.advisor | Seifu Daniel | |
| dc.contributor.author | Addisu Sisay | |
| dc.date.accessioned | 2020-05-27T12:47:55Z | |
| dc.date.accessioned | 2023-11-29T04:18:23Z | |
| dc.date.available | 2020-05-27T12:47:55Z | |
| dc.date.available | 2023-11-29T04:18:23Z | |
| dc.date.issued | 2019-05 | |
| dc.description.abstract | Background: Breast cancer has been shown as commonest type of cancer in Ethiopian women. It a heterogeneous disease in terms of clinical, histopathological and biological characteristics. Some of the molecular differences underlying this heterogeneity were previously discovered by genetic expression profiles and validated by immunohistochemical surrogates. Hence, this study was carried out to analyze breast cancer by histopathological features and immunohistochemical markers, and interrelationship among them in Ethiopian female breast cancer cases. Method: This study was a retrospective analytical study done on clinically and pathologically confirmed breast cancer cases that underwent modified radical mastectomy (MRM) from June, 2014 – June, 2015. The primary breast tumor tissues with the corresponding axillary lymph nodes were examined for histopathological features including histologic type, tumor size, nodal status and grade. Evaluation of the molecular markers including ER, PR, EGFR and VEGF-A were done by immunohistochemistry using formalin-fixed and paraffin-embeded tissues. Data was analyzed using SPSS 24.0. The p value < 0.001). No significant correlations were observed between age and histopathologic features (except tumor size), age and molecular markers, the molecular markers and histopathological features (except for PR), VEGF and standard molecular markers, EGFR and PR. status and grade. Evaluation of the molecular markers including ER, PR, EGFR and VEGF-A were done by immunohistochemistry using formalin-fixed and paraffin-embeded tissues. Data was analyzed using SPSS 24.0. The p value < 0.001). No significant correlations were observed between age and histopathologic features (except tumor size), age and molecular markers, the molecular markers and histopathological features (except for PR), VEGF and standard molecular markers, EGFR and PR. Conclusion: Our study showed that majority of our breast cancer patients were younger age with large tumor size, lymph node positive and poorly differentiated tumors. Younger age women are more likely to present with larger tumor size as compared to older age groups. EGFR expression was most likely associated with ER and PR negative tumors. Assessment of multiple molecular markers aids to understand the biological behavior disease prognosis in Ethiopian population. It might also help to predict which group of patients might get more benefit from the selected treatment strategies and which are not. Key words: Breast cancer, ER, PR, EGFR, VEGF-A, IHC, Histopathological features | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21346 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Breast cancer, ER, PR, EGFR, VEGF-A, IHC, Histopathological features | en_US |
| dc.title | Histopathological Characteristics and Immunoh is to Chemical Biomarkers of Invasive Breast Cancer in Ethiopia Women | en_US |
| dc.type | Thesis | en_US |