To Describe Health Related Quality of Life, and its Predictive Factors on Cervical Cancer Patients in two Teaching Hospitals, Addis Ababa, Ethiopia, 2021.
No Thumbnail Available
Date
2021-08
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: Cervical cancer is the second most prevalent malignancy in Ethiopia associated
with high mortality and morbidity. Nonetheless, few efforts have been made to assess the
patients’ HRQOL, and its predictive factors in Ethiopia.
Objective: To describe Health Related Quality of Life, its predictive factors of cervical cancer
patients in Tikur Anbessa Specialized Hospital and Saint Paul’s Hospital Millennium Medical
College, Addis Ababa, Ethiopia.
Methods: An institutional based cross-sectional study was conducted in Tikur Anbessa
Specialized Hospital and Saint Paul’s Hospital Millennium Medical College, from Feb to June,
2021G.C. A total of 264 cervical cancer patients were interviewed using the Amharic version of
European Organization for Research and Treatment of Cancer module (EORTC QLQ-C30), and
cervical cancer module (EORTC QLQ-CX24) .The Amharic versions of both instruments were
previously validated .The data was analyzed using SPSS version 25 and Microsoft Office Excel
2010. ANOVA and stepwise binary and multivariable logistic regression were employed to
determine mean difference and significant associations.
Results: The mean Global quality of life (GQOL) was (mean± SD =42.57± 23.31) and with the
least affected function being physical functioning (mean± SD =76.39± 23.24) and highest social
function (mean± SD =50.40± 32.19). For the symptom scales, the financial difficulty had the
highest mean of (mean± SD =57.83 ±35.34) and with the exception of diarrhea (mean± SD=
20.08± 29.87) and dyspnea (mean± SD= 22.89± 29.87), all the other items indicated moderate
to high symptoms. The EORTC QLQ-CX24 symptom scales the least affected score was on
Lymph adenoma (mean± SD =27.71±37.11) and highest affected score was for sexual worry
(mean± SD= 51.81+32.197). As stage increases there was a statistically significant reduction in
GQOL (p = 0.005) .Age, educational status and monthly income has association with GQOL
.Being in the age group <40years affects 2.12 times the GQOL compared to the other variables
(AOR =2.12, 95%CI =0.23-18.90). The patients monthly income <600ETB affects the GQOL 1.7
times (AOR=1.74, 95% CI = 0.34-8.93). Participants affected body image and feeling of lymph
adenoma was the only two variables which had significant association with GQOL. Once sense
of body image affected 1.88 times (AOR=1.88, 95%CI=0.42-8.45) the GQOL and 1.39 times
(AOR=1.39, 95%CI=0.51-3.81) if affected feeling of lymph adenoma.
Conclusions: GQOL, physical function, role function, cognitive functions, financial difficulties,
insomnia and fatigue were the most affected however social function, dyspnea and diarrhea were
less affected components of HRQOL of cervical cancer patients. Age , marital status, educational
status, occupational status ,monthly income , stage of the disease ,time since diagnosis and
planned type of treatment were some of the different socio demographic and medical factors
which were associated with health related quality of life of cervical cancer patients.
Description
Keywords
Cervical cancer, Health related quality of life, HRQOL, EORTC QLQ-C30, EORTCQLQ-CX24, Ethiopia