Prevalence of Hepatitis B Virus in Patients with Diabetes Mellitus: A Comparative Cross Sectional Study at Woldiya General Hospital, Ethiopia
| dc.contributor.advisor | Gebre-Selassie, Solomon(PhD) | |
| dc.contributor.advisor | Mihret, Adane(PhD) | |
| dc.contributor.author | Mekonnen, Daniel | |
| dc.date.accessioned | 2018-06-29T13:18:55Z | |
| dc.date.accessioned | 2023-11-05T09:35:57Z | |
| dc.date.available | 2018-06-29T13:18:55Z | |
| dc.date.available | 2023-11-05T09:35:57Z | |
| dc.date.issued | 2011-05 | |
| dc.description.abstract | Background: Hepatitis B Virus (HBV) infection and its sequelae (cirrhosis and liver cancer) are major global health problems. Overall prevalence in Ethiopia varies from 4.7-16.8% for HBsAg and 70-76.4% for at least one marker positive. During recent years evidence has accumulated that in patients with diabetes mellitus, phagocytosis by polymorpho nuclear leukocytes is impaired and disturbances in cell-mediated immune responses can be demonstrated. Cell-mediated immunity is involved in the defense against viruses as well as in that against Mycobacterium and Fungi. However, no increased incidence of viral infections like HBV has yet been reported in patients with diabetes. Objective: To determine the prevalence of HBsAg in patients with diabetes mellitus and to compare those with the non diabetes. It also asses associated factors and liver function tests (LFT); and compare Diabetic and non Diabetic subjects; and HBV positive and negative participants. Methods: The study was a comparative cross sectional study design conducted at Woldiya General Hospital using 108 consented study populations from each study group during the period November, 2010 through January, 2011. A convenience sampling method was used. A total of 216 samples were tested for HBsAg serostatus using VISITECT HBsAg rapid test kit and LFT tests using Humastat 80 chemistry analyzer. Data entered to SPSS-16 and then analyzed using the same soft ware. Multivariate logistic regression was used to see the association of HBV with clinical history of participants and sociodemographic variables. All tests were two-sided with α-level of 0.05 and 80% power. Results: prevalence of HBsAg was equal between diabetes and non diabetes, 3.7% indicating that there was no difference between the two groups. No any Sociodemographic and clinical history of participants were associated with HBV infection (p>0.05) except chronic liver disease. Conclusion: In this study a positive relation was not indicated between HBV and Diabetes and DM in the study area did not predisposed to HBV infection than the rest of the population. Key word: hepatitis B virus, prevalence,association ,diabetes millitus,non diabetics. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/5107 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | hepatitis B virus | en_US |
| dc.subject | Prevalence | en_US |
| dc.subject | Diabetes millitus | en_US |
| dc.subject | Non diabetics | en_US |
| dc.title | Prevalence of Hepatitis B Virus in Patients with Diabetes Mellitus: A Comparative Cross Sectional Study at Woldiya General Hospital, Ethiopia | en_US |
| dc.type | Thesis | en_US |