Prevalence of Mycobacterium Tuberculosis, its Rifampicin-Resistance Pattern an Associated Factors Among Presumptive Pulmonary and Extra Pulmonary Tuberculosis Patients at Madda Walabu University Goba Referral Hospital Southeast Ethiopia
No Thumbnail Available
Date
2021-07
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Background: Drug resistant Mycobacterium tuberculosis is one of the serious public health trouble that intimidating progress made in tuberculosis cases and control in several countries including Ethiopia. Rifampicin resistance is an indicator for drug-resistant Mycobacterium tuberculosis, because it disclose the existence of more than 90% Isoniazid resistance. Early detection of drug-resistant tuberculosis is crucial for patient management and infection control.
Objective: This study was designed to assess the prevalence of My cobacterium tuberculosis, its Rifampicin-resistance pattern and associated factors among presumptive Pulmonary and Extra Pulmonary Tuberculosis patients at Madda Walabu University, Goba Referral Hospital, Southeast Ethiopia.
Methods: Hospital based cross-sectional study design was carried out from October 22, 2020 to February 7, 2021. Detection of Mycobacterium tuberculosis and resistance to Rifampicin pattern was determined by using Gene pert MTB/RIF assay. Data were entered and analyzed by SPSS version 23.0. Bivariate and multivariate analyses were used to examine the relationship between dependent and independent variables. Less than 0.05 P-value was used to show significance.
Results: A total of 301 presumptive tuberculosis patients were included in the study; of these, 46 (15.3%) of them were identified as having Mycobacterium tuberculosis by the GeneXpert MTB/RIF assay, 2/46 (4.35%) were resistant to Rifampicin and 4/46 (14.8%) patients were TB/HIV co-infected. From the total of M. tuberculosis detected 40 (16.7%) were identified in pulmonary and 6 (9.8%) were in extra-pulmonary presumptive patients. Rifampicin-resistant M.
tuberculosis was detected in 2 patients who had a history of taking Anti tuberculosis drugs and no in new patients.
Conclusion and recommendation: Previous history of tuberculosis treatment and having close contact history with tuberculosis patients were found as an important associated factors that enhance the prevalence of tuberculosis. This indicates the mandate to make better and oversee the treatment protocol to control the burden of tuberculosis.
Description
Keywords
Rifampicin resistant M. tuberculosis, GeneXpert MTB/RIF assay, Risk factors