Assesment of Magnitude and Associated Factors of Neonatal Hyperbilirubinemia at Neonatal Intensive Care Unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2017
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2017-06
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Addis Ababa University
Abstract
Background: Neonatal hyperbilirbinemia (NH) is a recognized cause of brain damage andbilirubin encephalopathy resulting in long-term sequel like sensory-neuronal hearing loss in thesurvivors and death.
Objective: To assess magnitude and associated factors of NH among neonates admitted atneonatal NICU from September 11/2014 to September 11/2016 in TASH.
Methodology: Retrospective cross sectional study was conducted on neonates admitted at NICUof TASH and 356 neonates were systematically selected among all admitted neonates. Study wasconducted from January 2017 to June 2017. Supervisors and data collectors were BSc healthprofessionals. Pre-test was conducted on 5% of sample before the starting of actual datacollection. Checklist was adopted and modified from literatures to collect data. Supervisors werechecked the collected data daily for completeness. Data was first entered to Epi Info version 7and exported to SPSS version 20.0 to clean and analyze data. Relation between dependent andindependent variables were assessed and presented using odd ratios and confidence intervals.Statistical association was considered as significant if p-value was less than 0.05. Ethicalclearance for the study was received from Addis Ababa University, College of Health Sciences.A formal letter was written to TASH and permission was secured at all levels.
Result: Medical record of 356 neonates were reviewed and 160(44.9%) of them developed NH.89(25%) of males and 71(19.9%) of females were developed neonatal hyperbilirubinemia. Theirserum bilirubin level was from 5.6mg/dl to 77.7mg/dl. Among associated factors of NH: ABOincompatibility 57(35.6%), sepsis 30(18.8%), idiopathic cause 22(13.8%), breast feedingjaundice 16(10%) and Rh isoimmunization 14(8.8%). Age of neonates was significantlyassociated with neonatal hyperbilirubinemia in logistic regression.
Conclusion and Recommendation: Magnitude of neonatal hyperbilirubinemia in this study wasnear to half of selected neonates. Among identified associated factors of NH, ABOincompatibility and sepsis were the leading cause. So, early prevention and timely treatment ofNH is important since it was a cause of long term complication and death in neonates.
Keyword: Magnitude, Neonatal hyperbilirubinemia
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Keywords
Magnitude Neonatal hyperbilirubinemia, Neonatal hyperbilirubinemia