Assesment of Magnitude and Associated Factors of Neonatal Hyperbilirubinemia at Neonatal Intensive Care Unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2017
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Date
2017-06
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Addis Ababa University
Abstract
Background: Neonatal hyperbilirbinemia (NH) is a recognized cause of brain damage and
bilirubin encephalopathy resulting in long-term sequel like sensory-neuronal hearing loss in the
survivors and death.
Objective: To assess magnitude and associated factors of NH among neonates admitted at
neonatal NICU from September 11/2014 to September 11/2016 in TASH.
Methodology: Retrospective cross sectional study was conducted on neonates admitted at NICU
of TASH and 356 neonates were systematically selected among all admitted neonates. Study was
conducted from January 2017 to June 2017. Supervisors and data collectors were BSc health
professionals. Pre-test was conducted on 5% of sample before the starting of actual data
collection. Checklist was adopted and modified from literatures to collect data. Supervisors were
checked the collected data daily for completeness. Data was first entered to Epi Info version 7
and exported to SPSS version 20.0 to clean and analyze data. Relation between dependent and
independent variables were assessed and presented using odd ratios and confidence intervals.
Statistical association was considered as significant if p-value was less than 0.05. Ethical
clearance for the study was received from Addis Ababa University, College of Health Sciences.
A formal letter was written to TASH and permission was secured at all levels.
Result: Medical record of 356 neonates were reviewed and 160(44.9%) of them developed NH.
89(25%) of males and 71(19.9%) of females were developed neonatal hyperbilirubinemia. Their
serum bilirubin level was from 5.6mg/dl to 77.7mg/dl. Among associated factors of NH: ABO
incompatibility 57(35.6%), sepsis 30(18.8%), idiopathic cause 22(13.8%), breast feeding
jaundice 16(10%) and Rh isoimmunization 14(8.8%). Age of neonates was significantly
associated with neonatal hyperbilirubinemia in logistic regression.
Conclusion and Recommendation: Magnitude of neonatal hyperbilirubinemia in this study was
near to half of selected neonates. Among identified associated factors of NH, ABO
incompatibility and sepsis were the leading cause. So, early prevention and timely treatment of
NH is important since it was a cause of long term complication and death in neonates.
Keyword: Magnitude, Neonatal hyperbilirubinemia
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Keywords
Magnitude, Neonatal hyperbilirubinemia