Assessment of Drug Related Problems in Pediatric Ward of Zewditu Memorial Referral Hospital, Addis Ababa, Ethiopia
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Date
2015-03
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Addis Ababa University
Abstract
Although medications play a vital role in the cure, palliation and inhibition of disease they also expose patients to drug-related problems (DRPs), which are common in hospitalized patients. Pediatrics are risky population to be affected easily by DRPs, as dynamic and kinetic behaviors of drugs in this population are usually different than adults. The focus of this study was to assess DRPs in the pediatric ward of Zewditu memorial referral hospital (ZMRH). A retrospective study was conducted on 285 randomly selected patients. Data was obtained through review of physician medication orders and patients’ files. The incidence and type of DRPs were studied and documented using the Pharmaceutical care network Europe foundation (PCNE) classification system. Out of the 1055 medication orders reviewed, a total of 106 DRPs were identified in 90 patients with an incidence of 31.57%.The most frequently identified DRPs were dosing problems of drugs (42.45%). This was followed by drug-drug interactions (38.67%), and adverse drug reactions (8.49%). The number of prescribed drugs (AOR=2.3, 95% CI: 1.3-4.3; P=0.007) and total number of disease conditions (AOR=4.8, 95% CI: 1.9, 12.1; P=0.001) were potential risk factors for occurrence of DRPs. Based on the results drug related problems were common in this study, the most frequent were dosing problems and drug-drug interactions. Poly pharmacy and total number of disease conditions were potential risk factors. Key words: Drug related problems, pediatrics, Ethiopia
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Drug related problems; pediatrics, Ethiopia