Evaluation of the Diuretic Activity of the Aqueous and 80% Methanol Leaves Extracts of Ficus Sur Forssk (Moraceae) in Rats
| dc.contributor.advisor | Pro.Makonnen, Eyasu | |
| dc.contributor.author | Ayele, Mesfin | |
| dc.date.accessioned | 2020-12-20T06:45:05Z | |
| dc.date.accessioned | 2023-11-06T08:08:00Z | |
| dc.date.available | 2020-12-20T06:45:05Z | |
| dc.date.available | 2023-11-06T08:08:00Z | |
| dc.date.issued | 2020-05 | |
| dc.description.abstract | Ficus sur Forssk (Moraceae), commonly known as cape fig, is traditionally used in treatment of many diseases and ailments. Although investigations on different pharmacological activities of the plant have been conducted, its folklore use for diuresis has not yet been studied. The current study, therefore, Ficused on the diuretic activity of aqueous and 80% methanol leaves extracts of Ficus sur in rats. Rats were randomly assigned into eight groups each consisting of six rats for diuretic test. The negative control group was treated with distilled water (2 mL/100gm); whilst positive control group was treated with furosemide (10 mg/kg). The doses (100mg/kg, 200mg/kg, and 400mg/kg) of aqueous and 80% methanol extracts were administered to rats in group III-VIII, and urine volume was recorded every hour until the end of the fifth hour, and cumulative urine volume of each rat was taken. Then, diuretic activity, diuretic index, saliuretic index, natriuretic index and carbonic anhydrase inhibition index were calculated to make comparison among the groups. As an electrolyte excretion of all doses of the extracts showed significant natriuresis (p<0.001) and chloriuresis (p<0.01), the middle (200mg/kg) and the highest (400mg/kg) doses of both the aqueous and 80% methanol extracts significantly increased diuresis at the fifth hour (p<0.001) compared to the negative control, though it was less than that of the positive control. In addition, aqueous extract displayed more significant diuretic effect than 80% methanol extract. The aqueous and 80% methanol extracts produced alkaline urine. The crude leaves extracts of Ficus sur increased urinary excretion and concentration of urinary electrolytes in a dosedependent manner. These findings uphold the traditional use of Ficus sur as diuretic agent as claimed by traditional healers. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/24199 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Ficus sur, Diuretic activities, Urinary electrolyte, Furosemide, Rat, Aqueous extract, 80% Methanol extract. | en_US |
| dc.title | Evaluation of the Diuretic Activity of the Aqueous and 80% Methanol Leaves Extracts of Ficus Sur Forssk (Moraceae) in Rats | en_US |
| dc.type | Thesis | en_US |