Attempts Towards the Synthesis of Substituted Pyrrolines
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Date
1982-06
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Addis Ababa Universty
Abstract
In this project, the reactions of several functionalized
compounds possessing the nicotine skeleton have been
investigated. Studies also have been conducted on
the cycloaddition reactions of C-pyridyl-h-methylnitrone
with three olefinic compounds namely, allyl chloride,
allyl bromide and allyl alcohol. Plausible mechanisms
have been suggested for the formation of nicotine and nicotyrine
by the reduction of 5-methoxycotinine and related
compounds with lithium aluminum hydride.
In the course of this work four new compounds, namelp
4-hydroxynicotine, 4-chloronicotine, 4-hydro:<y~l-methy1
-2-phenylpyrrolidine and 4-methoxy-l-methyl-2~phenylpyrrolidine,
have been synthesized and their structures
established
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Keywords
Substituted Pyrrolines