Prevalence and Drug Susceptibility Pattern of Neisseria Gonorrheaamong Symptomatic Women Attending Gynecologic OPD in Hawassa Referral Hospital.
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Date
2011-02
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Addis Ababa University
Abstract
Background: Gonorrheae is asexually transmitted diseasecaused by the bacterium Neisseriagonorrhea for which humans are the only natural host. It is fastidious Gram-negative cocci transmitted by human-to-human contact. Gonococcal infection highly adapted to the genital tractandoften causing asymptomatic and undetected infection in females in which the highest rates are found mainly in female’s of reproductive age group. There are a number of antibiotics for treatment of gonorrhea in which the preferences vary with the local situation.
Objective: To determine the prevalence and drug susceptibility pattern of Neisseria gonorrheaamong symptomatic women attending gynecologic OPD in Hawassa Referral Hospital.
Methods: A cross-sectional study was conducted from December 2010 to February 2011 at Hawassa University Referral Hospital Hawassa, Ethiopia. During the study period, all women patients visited to gynecologic OPD with suspected of gonococcal infection were included. The inclusion criteria for the selection of215 women of reproductive age group was based on any sign and symptoms for STD up on clinical examination of symptom aticpatients at gynecologic OPD. Endocervical swab were collected by the attending physician. The Presence of gonorrhea was confirmed by culture, Gram staining and biochemical tests. Antimicrobial sensitivity test was performed using disc diffusion method and the result was interpreted accordingly.
Result:Of the total 215 patients examined, 11 (5.1%) were confirmed to have gonococcal infection. The highest prevalence was observed in age group 20-24 which is 5/11 (45.5%) andthere is no statistical significant association (p>0.05). The susceptibilitypatterns were done against 11 antimicrobial agents by the agar disc diffusion technique. Low level of susceptibilityto quinolones (ciprofloxacin 55%, ofloxacin 64% & lomefloxacin 64%) was reported.
Conclusion:The findings from this study indicate that gonococcal infection was moderately higher combined with high Neisseria gonorrhearesistance.
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Neisseria gonorrhea(NG), women infection,Thayer-Martinmedium