Insulin Resistance, Dyslipidemia and Cardiovascular Disease Risk in HIV-1 Infected Adults Receiving Protease Inhibitor Based Combined Antiretroviral Therapy in the Art Clinic of Tikur Anbessa Referral Hospital.
| dc.contributor.advisor | seifu Daniel | |
| dc.contributor.advisor | Tsegaye Aster | |
| dc.contributor.advisor | Amogne Wondwossen | |
| dc.contributor.author | Amare Hagos | |
| dc.date.accessioned | 2021-09-30T11:14:27Z | |
| dc.date.accessioned | 2023-11-29T04:18:26Z | |
| dc.date.available | 2021-09-30T11:14:27Z | |
| dc.date.available | 2023-11-29T04:18:26Z | |
| dc.date.issued | 2011-12 | |
| dc.description.abstract | Treatment with AIDS. However, it has also increased the incidence of various metabolic disorders, in particular insulin resistance accompanied by dyslipidaemia, hyperglycaemia and lipodystrophy. This is often predispose to type 2 diabetes and increased mortality from cardiovascular disease which is more common in protease inhibitor based regimen. This cross sectional study was designed to assess the occurrence of insulin resistance, dyslipidemia and cardiovascular disease risk in HIV-1 infected adults taking protease inhibitor based combined antiretroviral therapy and to compare with those taking NNRTI-based regimen in a total of 134 subjects that contain equal number of cases and controls. Accordingly, variables like age, sex, type of regimen, duration of ART were collected and anthropometric variables and blood pressure was measured. Moreover, biochemical variables like glucose, insulin and lipid profile were determined using standard and calibrated clinical chemistry analyzers along with a parallel control run in a fasting serum sample collected from the patients. HOMA and total cholesterol to HDL ratio as well as triglyceride to HDL ratio were also calculated using a standard formula. The results revealed an elevated serum triglyceride concentration and a trend toward increase in insulin resistance on patients treated with PI-based regimen (cases), compared to NNRI-based regimen (controls). Insulin resistance was observed in 34.3% of the cases as compared to 28.4% in the controls as assessed by HOMA-IR. HOMA-IR mean values were similar and did not differ significantly between the two groups. Dyslipidemia was also more prevalent among the cases as compared to the controls. Accordingly, 58.2% patients on PI based regimen and 47.8% on NNRTI-based regimen had high cholesterol levels (> 5.1 mmol/L). However, the difference was not statistically significant (p = 0.226) and the same is true for their means (210 ± 41versus 200 ± 35, P = 0.137). Equally higher percentage of patients had high LDL level (>2.6 mmol/L) on both groups and there was no statistically significant difference in the proportions as well as mean values between the two groups (65.7% versus 64.2%, p = 0.856; 109 ± 32 versus 112 ± 31, p = 0.584). In this study, it appeared that hypertriglyceridemia (>1.7 mmol/L) affected almost three fourth (74.6%) of the patients on PI-based regimen and 34.3% on NNRTI-based regimen (p 3.8) (p Taken together, this study concluded that patients on PI- based cART have higher risk of developing insulin resistance and cardiovascular problems. Key words:. Protease inhibitors, Insulin resistance, Dyslipidemia, HOMA, Metabolic syndrome | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28020 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Protease inhibitors, Insulin resistance, Dyslipidemia, HOMA, Metabolic syndrome | en_US |
| dc.title | Insulin Resistance, Dyslipidemia and Cardiovascular Disease Risk in HIV-1 Infected Adults Receiving Protease Inhibitor Based Combined Antiretroviral Therapy in the Art Clinic of Tikur Anbessa Referral Hospital. | en_US |
| dc.type | Thesis | en_US |