Evaluating Microbiota Signatures, Intrinsic Subtypes, PIK3CA Gene Mutations and Alternative Diagnostic Modalities Among Ethiopian Breast Cancer Patients

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dc.contributor.advisorTamrat Abebe
dc.contributor.authorZelalem Desalegn
dc.date.accessioned2025-08-12T19:51:50Z
dc.date.available2025-08-12T19:51:50Z
dc.date.issued2024-06-13
dc.description.abstractFemale breast cancer incidence has risen to unprecedented levels. It is a complex disease presented with distinct morphology, biological behaviors, clinical outcome and prognosis. Consequently, classification of breast cancer, understanding the molecular events including PIK3CA mutations and exploration of environmental factors including microbiota have a central role in understanding tumor biology. However, there is limited evidences in sub-Saharan Africa (SSA) context including Ethiopia; therefore, this study was conducted to generate evidence-based data to improving breast cancer care in Ethiopia. Additionally, considering the limited infrastructure for breast cancer diagnosis, we did method evaluation between PCR methods and immunohistochemistry to suggest alternative methods
dc.identifier.urihttps://etd.aau.edu.et/handle/123456789/6471
dc.language.isoen_US
dc.publisherAddis Ababa University
dc.subjectBreast cancer
dc.subjectEthiopia
dc.subjectIHC
dc.subjectIntrinsic subtypes
dc.subjectMicrobiota
dc.subjectMutation
dc.subjectOverall survival
dc.subjectPCR
dc.subjectPIK3CA
dc.subjectPrognostic features
dc.titleEvaluating Microbiota Signatures, Intrinsic Subtypes, PIK3CA Gene Mutations and Alternative Diagnostic Modalities Among Ethiopian Breast Cancer Patients
dc.typeThesis

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