Histopathologic Patterns of Uterine Corpus Neoplasms in in a Tertiary Level Teaching Hospital,CHS,Tikur Anbessa Specialized Hospital, AAU, Addis Ababa, Ethiopia, a Retrospective Study over a 5 year period, August ,2016-2020.
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Date
2020-10
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Addis Ababa University
Abstract
Background: Malignant Uterine corpus tumors (UCT ) are increasing in alarming rate throughout the word. Even if most common of this endometrial carcinoma; is prevalent in western & high income countries ,due to change in life style, increasing obesity, metabolic syndrome and exogenous hormone use its incidence is raising in middle income & developing nations. Many studies of large series has been conducted worldwide on uterine corpus tumors. However, in Ethiopia, epidemiological analysis of these tumors are very scarce. The present paper is a retrospective study of 1126 cases of uterine corpus lesions from a single institution, in Addis Ababa University, TASH. According to global cancer observatory estimate in2018 there were total 67,573 new cancer cases, and 47,954 deaths in Ethiopia. Out of this corpus uterine contributes 762 new cases (1.13%) and 404 deaths( 0.08) And Addis Ababa Cancer Registry 2015 report had estimated 961 new cases of uterine cancer ranked 9th commonest cancer among women; with ASIR OF 3.2% and CIR 1.9 %.
Objectives: The aim of this study is to determine histopathologic patterns of uterine corpus lesions and their frequency .in Tikur Anbessa Specialized Hospital.
Methods and materials: A retrospective analysis of histopathological pattern of Uterine corpus tumors was carried out in the Department of Pathology, college of health sciences, Tikur Anbessa Specialized Referral Hospital (TAH), Addis Ababa university , Addis Ababa, Ethiopia. Patients data was retrieved from the archives of the department of Pathology for a period of 5 years from August 2016-2020 and analyzed using spss version 26.
Result: Out of 1126 cases ,benign lesions accounted 88.4% and the rest 11.6% are malignant lesion .Leiomyoma is most frequent benign lesions. with peak age b/n 31-40yrs.and cellular leiomyoma is commonest histologic type. From malignant lesions ,epithelial origin is the most frequent accounting 55% followed by MMMT (13%), Leiomyosarcoma (9.2%), ESS ,choriocarcinoma, Invasive mole each contribute ( 6.9%).other sarcoma’s group; one rhabdomyosarcoma & two undifferentiated pleomorphic sarcoma total 3 cases (2.3%) is found. Endometroid carcinoma is most common endometrial carcinoma type. Mean age of occurrence for endometrial carcinoma is younger than endometrial sarcomas.
Conclusion: In this study benign neoplasms are way more prevalent than malignant lesions,but for age above 50 yr malignancy appeared to be a common cause of uterine bleeding. Both benign & malignant lesions have common clinical presentation majority having AUB ,b/s of this histopathology remains the mainstay of final and definitive diagnosis.
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Histopathologic patterns , uterine corpus, neoplasms