Preparation, Characterization and Evaluation of Cross-Linked Sweet Potato [Ipomoea batatas (L.) Lam.] Starch for Sustained Release Tablet Formulation
| dc.contributor.advisor | Birhanu,Gebremariam(Dr.) | |
| dc.contributor.advisor | Wondu,Kebede | |
| dc.contributor.author | Woldeyohannes,Asnake | |
| dc.date.accessioned | 2024-04-23T10:55:22Z | |
| dc.date.available | 2024-04-23T10:55:22Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Along with cellulose and chitin, starch is one of the most prevalent biopolymers on earth and serves as a significant reserve polysaccharide in higher plants. Starch is an important ingredient in many products used in the food, pharmaceutical, and other industries. Despite its importance, starch is rarely regarded as an ideal raw material because of its uncomplimentary properties. Thus, modifications such as physical, chemical and enzymatically modifications are necessary to produce starch derivatives with improved pharmaceutical properties. The aim of this study was to chemically cross-link sweet potato (Ipomoea batatas (L.) Lam) starch using sodium hexametaphosphate and evaluate its potential for sustained release applications. Sweet potatoes (Ipomoea batatas (L. Lam)) starch was extracted, and then it was subjected to three different concentrations (10%, 15% and 20%) of SHMP treatment to create cross-linked sweet potato starches (CLSPSs): 10%-CLSPS, 15%-CLSPS, and 20%-CLSPS, at a temperature of 55°C, and the cross-linking process took place for 8 hours. The degree of cross-linking for 10%-CLSPS, 15%-CLSPS, and 20%-CLSPS were 67.73% +1.86, 75.35% + 2.99, and 77.45% ± 0.34, respectively. Increasing the concentration of sodium hexametaphosphate used for cross-linking starch leads to higher degree of cross-linking, which in turn reduces the solubility and swelling power of the starch. This is because the cross-linking process produces a more rigid and compact structure, making it more difficult for water molecules to penetrate and interact with the starch molecules. Moreover, in the moisture sorption study, it was observed that the water uptake capacity of the starch decreased with an increase in cross-linking. Furthermore, the cross-linked starch exhibited improved physical properties such as enhanced compressibility, powder density, flowability, and heat stability as compared to its native starch. X-ray crystallography showed that the CLSPSs had a crystal structure with a diffraction angle of 15.33°, 17.22°, and 22.96°, and nearly the same crystallinity as the native starch. SEM photographs showed minor morphological differences as it is observed on the powder surfaces of both native and CLSPS. The Fourier Transform Infrared Spectroscopy and Differential scanning calorimetry investigations supported the conclusion that there was no incompatibility between the model drug glibenclamide and CLSPS polymer. IX Tablets were prepared using various amount of cross-linked starch by direct compression method the prepared tablets were evaluated for the physical properties such as weight variation, thickness, hardness, friability, disintegration time and in vitro drug release studies. Preliminary studies result suggested the drug release characteristics from matrix tablets could be influenced by the concentration of cross-linking agent, and the ratio of cross-linked starch. Additionally, the suitability of methods used for determining these characteristics was also assessed. According to the study's results, the prepared tablets had satisfactory physical properties and met the standards. The tablets prepared with 10%-CLSPS showed a glibenclamide release percentage of 88% at 6 hours, while the tablets made with 15%-CLSPS released 85% of the drug at the same time. The tablets prepared with 20%-CLSPS released 81.2% of the drug close to 12 hours. The tablet matrix gelling capabilities of CLSPS, which created a gel-like network around the drug particles and slowed the rate of drug release, were thought to be responsible for the sustained- release properties of the tablets. The Higuchi's model and the Kors meyer Peppa's models were determined to best fit in-vitro dissolution data after being subjected to numerous drug release kinetics models. It was identified that the "n" value for the diffusional release exponent, which indicates that drug release processes involved both polymer erosion and diffusion, ranged between 0.6303 and 0.7367. The drug release pathways were consequently categorized as anomalous or non- Fickian diffusion. In conclusion, the study findings suggest that cross-linked sweet potato starch is a more favorable option for utilization in pharmaceutical formulations due to its superior sustained- release properties. Therefore, it can be considered as a viable substitute polymer for achieving sustained-release effects. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/2796 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Cross-linked Starch | |
| dc.subject | Glibenclamide | |
| dc.subject | Matrix tablet | |
| dc.subject | Sodium hexametaphosphate | |
| dc.subject | Starch | |
| dc.subject | Sweet potato (ipomoea batatas (L). Lam) | |
| dc.subject | Sustained release. | |
| dc.title | Preparation, Characterization and Evaluation of Cross-Linked Sweet Potato [Ipomoea batatas (L.) Lam.] Starch for Sustained Release Tablet Formulation | |
| dc.type | Thesis |