Total Oxidant-Antioxidant Status Among Psoriatic Patients Attending at Alert Hospital, Addis Ababa, Ethiopia
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Date
2016-03
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Addis Ababa University
Abstract
Psoriasis is a chronic inflammatory skin disease characterized by the immune system
activation in which the genetic and environmental factors are involved that trigger the
development of skin lesions. Reactive oxygen species produced as a result of skin
inflammation may cause disorders of the antioxidant defense systems and increased
oxidative stress in psoriasis which was proposed to have to have a consequent function in
psoriasis.
Aim of the study: The presented research work was planned to evaluate oxidative stress by
measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index
in psoriatic patients.
Methods: A comparative cross-sectional study was undertaken with 45 clinically diagnosed
psoriatic patients without any drug therapy and 45 age-sexes matched healthy controls. The
severity of psoriasis was determined by Psoriasis area severity index. Out of total 45
Psoriasis patients, 22 were mild, 15 moderate and remaining 8 were severe psoriatic
patients. Levels of Total Oxidant Capacity, Total Anti-oxidant Capacity and Oxidative
Stress Index were measured in patients and controls.
Results: The present study showed significantly (p<0.001) increased levels of serum Total
Oxidant Capacity as well as Oxidative Stress Index (p<0.001) in psoriasis patients as
compared to controls and positively correlated with severity and duration of the disease.
Total Anti-oxidant Capacity levels were significantly (p<0.001) lower in patients than in
controls and negatively correlated with severity and duration of the disease.
Conclusion: These results provide some evidence regarding the role of increased reactive
oxygen species with decreased antioxidant activity in psoriatic patients.
Key Words: Total Oxidant capacity, Total Antioxidant capacity, Oxidative stress index
Psoriasis.
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Keywords
Total Oxidant capacity; Total Antioxidant capacity, Oxidative stress index Psoriasis.