Drug Therapy Problems among Ambulatory Patients with Type 2 Diabetes at Endocrine and Metabolism Unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
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2018-01
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Drug Therapy Problems among Ambulatory Patients with Type 2 Diabetes at Endocrine and Metabolism Unit of Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
Gebre Teklemariam Demoz
Addis Ababa University, 2018
Patients with diabetes are at high risk of drug therapy problems (DTPs), as they are outstanding to multiple-medications. To date, studies regarding DTPs in patients with diabetes are limited in Ethiopia. Thus, this study was aimed to assess the magnitude, pattern and factors associated with DTPs among patients with type 2 diabetes at Tikur Anbessa Specialized Hospital. A cross sectional study was conducted among 357 participants who fulfilled the inclusion criteria. Participants were interviewed using structured data collection format, involving medical chart review retrospectively. Drug therapy problems (DTPs) were assessed using Cipolle‘s classification system. Data were reported by mean/percentage and multivariate logistic regression analysis was performed to identify factors associated with DTPs. A total of 193 DTPs in 164(45.9%) of participants were identified. Most commonly identified DTPs were ineffective drug therapy 54(26.1%), need additional drug 52(25.1%) and dosage too low 47(22.7%), Factors independently associated with DTPs were female gender (Adjusted Odds Ratio [AOR] =2.21, 95%CI; 1.32-3.72), number of comorbidities (≥3) (AOR=3.18, 95%CI;1.21-8.38), non-adherence (AOR=4.52,95%CI;2.34-8.73). One-fourth (24.9%) of the participants were non-adherent to their medications. Factors associated with non-adherence were diabetes complications (AOR=2.02, 95%CI; 1.02-3.22), being female gender (AOR=1.71, 95%CI; 1.01-2.76) and primary and above level of education (AOR=0.42, 95%CI; 0.18-0.96). Drug therapy problems were substantially high. Ineffective drug therapy, need additional drug therapy and dosage too low, were commonly identified DTPs. Nearly one-fourth of the study participants were non-adherent to their medications. In response to this finding, tailored future intervention that target in prevention and resolution of those problems could be vital.
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Diabetes mellitus, drug therapy problems, medication adherence, Ethiopia