FIELD EVALUATION OF INACTIVATED WHOLE CULTURE OF CONTAGIOUS CAPRINE PLEUROPNEUMONIA VACCINE FOR ITS SAFETY AND IMMUNOGENICITY AT ADAMI TULU AGRICULTURAL RESEARCH CENTER OROMIA REGION, ETHIOPIA
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Date
2017
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Abstract
This study was conducted between December 2016 and May 2017 in East Shewa Zone Oromia Regional State Adami Tulu Agricultural Research Center to determine field performance (seroconversion) of contagious caprine pleuropneumonia inactivated whole culture commercial vaccine, produced by the National Veterinary Institute in Ethiopia. Study animals were screened for absence of Mycoplasma capricolum subsp capri pneumoniae specific antibody and then tested for evidence of seroconversion after vaccination on day 28th post vaccination by using competitive enzyme linked immuno- sorbent assay and then percent sero positivity and the difference in percent inhibition between pre vaccination and post vaccination sera was analyzed. The result of the current study showed that out of 358 study animals 246 (68.7%), CI= 63.6-73.5, showed seropositivity on day 28 post vaccination. The comparison of percent inhibition of pre vaccination and post vaccination sera showed that the percent inhibition of day 28 post vaccination sera to be significantly higher (p=0.0001) than the percent inhibition of pre-vaccination sera. In conclusion, the present study indicated that field vaccination of goats by inactivated whole culture vaccine induced sero-positivity in majority of the vaccinated goats. However, the field immunogenicity test needs to be conducted broadly in different areas to see the performance of the vaccine in different field conditions. Moreover, future controlled experimental studies with challenge infection after vaccination need to be conducted for further evaluation of the vaccine efficacy.
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MSc Thesis
Keywords
Adami Tulu Agricultural Research Center, inactivated whole culture vaccine, sero-conversion