Comparison of lipid profile, liver enzymes, CK and LDH of T2DM patients who were on statin attending Diabetic Clinic of Tikur Anbessa Specialized Teaching Hospital
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Date
2018-05
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Addis Ababa Universty
Abstract
Background: Diabetes mellitus (DM) is an epidemic disease affecting millions worldwide; the majority being T2DM. DM has been shown to be an important risk factor in the development of a variety of cardiovascular conditions becoming common in Ethiopia. Consequently, risk-reducing statin therapy is recommended for nearly all patients with diabetes at 40 years of age or older, regardless of cholesterol level. But, there are controversy regarding its safety.
Objective: The aim of this study was to assess and compare the level of lipid profile, liver enzymes, creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) in T2DM patients who were on statin therapy.
Methodology: Hospital based cross-sectional study was conducted on a total of 100 T2DM patients, divided into four groups (Group I, II, III and IV) each n = 25 T2DM patients who were on statin for 14 days–6months, 6–18months, ˃18months and who were not on statin therapy respectively. Convenient sampling technique was implemented till the required number has been achieved. Sociodemographic data was collected by using standardized questionnaire. Fasting blood was collected and lipid profile, liver enzymes, CK-MB, LDH and fasting blood sugar (FBS) were analyzed for all patients. Study was conducted from Mar - Sep, 2017.
Result: the mean value of total cholesterol and TAG were significantly lower among group III as compared to group I (P- value= 0.019 & 0.01). Similarly, LDL-c were significantly lower among group III as compared to group I (P=0.022) and group IV (P=0.027). In addition, mean values of lipid panel among the four study groups were higher than normal value. Serum ALT, AST and ALP, CK-MB and LDH were not show statistically significant differences among the study groups (p > 0.05). Mean value of ALT and AST were found within normal range while mean ALP was higher in all study groups. Fasting blood glucose was not different and but higher than normal values in all groups.
Conclusion: Statin taken for longer time has an effect in lowering total cholesterol, LDL-cholesterol and TAG in T2DM patients. CK-MB, LDH, liver enzymes (ALT, AST and ALP) and other parameters tested were more or less similar in all groups of study participants.
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Keywords
CK-MB, HMG-COA reductase, Lipid profile, Liver enzymes, Statin, T2DM, LDH