Membranes Interactions Mediated by Stickers: a Simulaion study
No Thumbnail Available
Date
2013-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
In this work, we investigate Moleculare dynamics simulation of Adhesion bond between
receptors and ligands. We modeled the ligand-receptor pairs(Adhesion bond) as Brownian
particle in viscous medium. Using the Langevin equation and employing the fourth
order Runge kutta method the position of the ligand-receptor pair is determined. Based
on the position's of ligand-receptor pairs the energy landscape of adhesion bond is obtained.
The coupled processes (formation and breaking) of adhesion bonds are simulated
by the Gillespie algorithms. These ligand-receptor interactions are modeled in the coupled
chemical reactions model where breaking and rebinding of the adhesion bonds are
stochastic. The Adhesion bond life time as the stochastic process that is rely on probability
for bond breaking and rebinding of di erent realizations of the SSA are used. The
stochastic relation between Nt,
and f with Nb
Nt
was examine
Description
Keywords
Moleculare dynamics simulation