Assessment of the magnitude of mortality from sepsis and septic shock and associated factors among patients admitted to adult Emergency departments
| dc.contributor.advisor | Temesgen Beyene | |
| dc.contributor.advisor | Tigist Zewdu | |
| dc.contributor.author | Assefa Petros | |
| dc.date.accessioned | 2026-06-22T10:56:04Z | |
| dc.date.available | 2026-06-22T10:56:04Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Sepsis and septic shock remain major causes of morbidity and mortality worldwide, with disproportionately high burden in low and middle-income countries. Evidence on early mortality and its determinants in Ethiopian Emergency departments is limited. This study aimed to determine the magnitude of mortality from sepsis and septic shock and associated factors among adult patients admitted to the emergency departments of Addis Ababa teaching tertiary hospitals. Methods: An institutional based retrospective chart review was conducted between October 2023 to October 2025 among the total of 141 eligible medical records of patients with sepsis or septic shock that admitted to the EDs at Tikur Anbessa Specialized Hospital and St. Paul Hospital Millenium Medical College. Multivariable logistic regression was conducted and adjusted odds ratios (AOR) with a 95% confidence interval (CI) were reported, and statistical significance was set at a p value of less than 0.05. Results: Among 141 patients, majority 57% were females and 42.6% were males, with median age range was 40-59years and about half, 47.5% of the had qSOFA score ≥ 2. The 24-hour emergency departments’ mortality among patients with sepsis and septic shock was 31.9% (95% CI: 24.2%–40.3%). Respiratory infections accounted for 49.6% of admissions, followed by gastrointestinal (38.3%) and central nervous system infection (4.3%). Mortality was significantly associated with multiorgan failure 2.9(1.1_7.4), length of EDs stay 12 hours 4.99(2.046_12.21), malignancy 2.6(1.1_6.2), qSOFA score ≥2 3.49(1.5_7.8) and comorbidities 3.3(1.125_ 9.84). Conclusion: Overall, the magnitude of ED mortality rate among patients with sepsis or septic shock admitted to EDs of Addis Ababa teaching hospitals was high. Respiratory and gastrointestinal infections were leading causes of death, emphasizing the need for targeted interventions. Clinical indicators such as altered mentation, hypotension, multiorgan failure, comorbidity, and prolonged ED significantly increased the risk of mortality. Enhancing early identification, optimizing resuscitation within the golden hours, and improving timely interventions are critical to reducing sepsis related mortality. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/8264 | |
| dc.language.iso | en | |
| dc.publisher | Addis Ababa Universtity | |
| dc.subject | Sepsis/Septic shock | |
| dc.subject | Early mortality | |
| dc.subject | Emergency department | |
| dc.subject | Addis Ababa | |
| dc.subject | Ethiopia. | |
| dc.title | Assessment of the magnitude of mortality from sepsis and septic shock and associated factors among patients admitted to adult Emergency departments | |
| dc.type | Thesis |