Assessment of hemodialysis-associated thrombocytopenia and other factors among patients on renal replacement therapy in Addis Ababa Ethiopia
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Date
2019-12
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Addis Ababa University
Abstract
Background; Hemodialysis is one of the renal replacement therapies, in addition to peritoneal dialysis and renal transplantation. Hemodialysis can improve morbidity and mortality in renal patients; however it has different multifactorial idiosyncratic complications that occur during the dialysis and/or during long term use of hemodialysis. Dialysis as treatment modality is extremely scarce in Ethiopia and affordable to only the rich.
Objectives: The objective of this study was to assess the prevalence of thrombocytopenia and associated factors among ESRD patient under hemodialysis in Addis Ababa Ethiopia from May 1st to June 1st, 2019:
Method: Institution based cross sectional study was conducted in Addis Ababa Ethiopia from May 1st to June 1st, 2019. 100 patients who were on hemodialysis during the study period were involved in the study. Platelet number was determined by flow cytometry. The collected data was checked for completeness, entered to computer and statistically analyzed using SPSS version 25.0
Results: The total number of patients in the study was 100. The mean age of the subjects was 40.25± 12.84 years, with a range of 18-76 years and 70% (70) of the study subjects were male. 85% of the study subjects had hypertension, and 19% had diabetes mellitus. Only 5% had co- morbidities likely to contribute to CKD, such as chronic glomerulonephritis and renovascular disease. The mean duration of hemodialysis was 0.78 ±0.42 years, with a range of 2 months to 3.5 years. The mean pre dialysis and post dialysis platelet count was 233.5×103±72.13cells/μl and 178×103 ±71.8 cells/μl respectively and thought it is in the normal range PT and PTT showed slight increase post HD (16.66±3.19) seconds compared to pre HD (15.4±5.69) seconds and 34±6.76 seconds compared to pre HD 33.8±5.34 seconds respectively. Age of patients COR=0.4(0.12, 1.356) and duration of treatment COR=0.43(.118, 1.531) were statistically insignificantly associated with thrombocytopenia.
Conclusion and recommendation: Over all prevalence of thrombocytopenia was higher in the study area and coagulation parameters; prothrombin time and partial thromboplastin time showed slight increase after hemodialysis among ESRD patient.
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Keywords
Hemodialysis, Thrombocytopenia