Comparative study of lipid profile and hematologic parameters among regular and first-time blood donors at National Blood Bank Service of Ethiopia.

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Addis Abeba University


Background: There is a shortage of blood in the blood banks due to limited donation. By and large, it is widely believed that blood donation has multiple health benefits. However, there are limited studies that support health benefits; As a result, assessing the lipid profile and hematologic parameters of the regular blood donors is an indispensable to evaluate an individual’s risk for chronic inflammation. Objective: We strived to compare lipid and haematological profiles of the regular and first- time blood donors in the National Blood Bank Service of Ethiopia. Materials and Methods: This comparative cross-sectional study was involved 104 samples (52 each of regular and first-time donors). Anthropometric parameters of donors measured and Blood was drawn from each participants for hematologic and lipid profile determination. Data were analyzed using SPSS version 21, Chi-square (χ²) was used to compare the relationship between categorical variables and independent t-test was used to compare the mean of the two groups. A p-value < 0.05 was considered statistically significant. Results: The mean total cholesterol, LDL-c, LDL-c/HDL-c and TC/HDL-c ratios were significantly lower in the regular blood donors than the first-time donors. Even though the level of HDL-c was higher in regular blood donors compared to first-time blood donors, it was not statistically significant. The mean of some hematologic parameters like a platelet, RDW, lymphocyte, and MCH were significantly lower in regular blood donors than first-time blood donors. BMI and WHR in regular donor were less than the first time donors, albeit statistically insignificant. Conclusions: Interestingly, blood donation has a significant health benefit by lowering TC, TG and LDL-c that have a potential risk for developing chronic inflammation.



Blood donation, lipid profile, hematologic parameters, National Blood Bank Service of Ethiopia, and chronic inflammation.