Characterization and evaluation of local Sterculia Setigera gum as a binder in paracetamol tablet formulations
| dc.contributor.advisor | Belete,Anteneh( PhD) | |
| dc.contributor.advisor | Birhanu,Gebremariam( Dr.) | |
| dc.contributor.author | Abiyu,Chilot | |
| dc.date.accessioned | 2024-04-23T10:53:03Z | |
| dc.date.available | 2024-04-23T10:53:03Z | |
| dc.date.issued | 2023-01 | |
| dc.description.abstract | Sterculia Setigera (S. Setigera) is a multipurpose wild plant in sub-Saharan Africa, primarily in Senegal and Ethiopia. It has many economical values. Sterculia Gum is an exudate product of Sterculia trees. It has a natural acid polysaccharide and produces galactose, rhamnose and galacturonic acid after hydrolysis. The aim of the present study is to characterize and evaluate the binding capacity of S. setigera gum in paracetamol tablet formulations. The binding effect of the Sterculia gum was determined in different concentration (1%, 3%, 5%, and 7%). By using wet granulation method the granules were formulated with an average weight of 650 mg of Paracetamol made from S. setigera gum, Acacia, and polyvinyl pyrrolidone. The granules were compressed into tablets using a rotary tablet compression machine. The tablets were evaluated for its properties such as hardness, friability, disintegration and dissolution test. The binding nature of Sterculia gum was compared with the reference binders (Acacia and PVP). The dry powder of S. setigera gum was obtained by solvent extraction, and its yielded 60% w/v. The Fourier transform infrared spectroscopic analysis showed that the formulation containing S. setigera gum was compatible with paracetamol in tablet formulations. The viscosity of Sterculia gum was higher than the reference binders. The tablet friability ranges from 1.4 to 0.44% and the disintegration time from 17 to 2 min. Tablets formulated with the S. setigera gum showed lower crushing strengths than those prepared with the reference binders. The drug release studies indicated that tablets prepared with PVP exhibited a higher release profile than Acacia and S. setigera gum binder. Sterculia gum is non-toxic, biodegradable and biocompatible excipient that can be employed as tablet binding agents. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/2785 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Gum | |
| dc.subject | Sterculia setigera | |
| dc.subject | Tablet binder | |
| dc.subject | Paracetamol | |
| dc.title | Characterization and evaluation of local Sterculia Setigera gum as a binder in paracetamol tablet formulations | |
| dc.type | Thesis |