Comparative assessment of serum lipid profile, complete blood count and viral load levels between HIV positive patients taking dolutegravir and efavirenz based antiretroviral therapy at wolkite health center, southern Ethiopia
| dc.contributor.advisor | Dr. Addisu, Sisay (PhD, Assistant Professor of Biochemistry) | |
| dc.contributor.advisor | Dr. Gnanasekaran, N (PhD, Assistant Professor of Biochemistry) | |
| dc.contributor.author | Sahilu, Bedilu | |
| dc.date.accessioned | 2021-11-01T11:30:59Z | |
| dc.date.accessioned | 2023-11-29T04:18:27Z | |
| dc.date.available | 2021-11-01T11:30:59Z | |
| dc.date.available | 2023-11-29T04:18:27Z | |
| dc.date.issued | 2021-08 | |
| dc.description.abstract | Background: Highly active antiretroviral therapy can achieve rapid HIV suppression and allows restoration of the immune system. However, their long-term use has been associated with various immunological, biochemical and haematological abnormalities such as dyslipidemia, insulin resistance, lactic acidosis, anemia, leukocytopenia, neutropenia and thrombocytopenia Objective: The main aim of this study was to compare lipid profile, complete blood count, and viral load levels between HIV positive patients taking dolutegravir and efavirenz based ART at Wolkite Health Center, Southern Ethiopia. Methods: Institution based comparative cross-sectional study was employed to include 75 efavirenz and 75 dolutegravir based ART treated patients, during their routine appointment using consecutive probabilistic sampling technique from May 2020 to July 2021 at Wolkite Health Center, Southern Ethiopia. Results: This study revealed patients on efavirenz based showed statistically significant (p = 0.030) decrease in HDL-C concentration as compared to dolutegravir based antiretroviral therapy users. The mean values of neutrophil was statistically significantly lower (p= 0.009) among dolutegravir based ART users. Moreover, the mean values of platelet count was statistically significantly higher (p = 0.033) in the efavirenz than the dolutegravir based antiretroviral groups. Viral load suppression rate among dolutegravir and efavirenz based antiretroviral therapy users were 94.6% and 86.7% respectively. Conclusion: Compared with efavirenz, dolutegravir based ART showed a better lipid profile and significant improvements in erythroid and lymphoid cell lines with lower prevalence of anaemia. Whereas, efavirenz significantly improved ameliorated platelet indices compared with dolutegravir based ART. Both of treatment regimens showed comparable efficacy in viral load suppression. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28457 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Dolutegravir, efavirenz, lipid, complete blood count, viral load | en_US |
| dc.title | Comparative assessment of serum lipid profile, complete blood count and viral load levels between HIV positive patients taking dolutegravir and efavirenz based antiretroviral therapy at wolkite health center, southern Ethiopia | en_US |
| dc.type | Thesis | en_US |