Treatment Outcomes of Patients With Visceral Leishmaniasis in Konso Zone, Southern, Ethiopia
| dc.contributor.advisor | Hailu Asrat | |
| dc.contributor.author | Garra Geyeto | |
| dc.date.accessioned | 2025-08-13T07:57:17Z | |
| dc.date.available | 2025-08-13T07:57:17Z | |
| dc.date.issued | 2023-10 | |
| dc.description.abstract | Background: Visceral leishmaniasis is one of the most neglected tropical diseases caused byprotozoa of the genus Leishmania. Leishmaniasis is estimated to affect 0.7–1 million people,with 350 million people at risk, globally. It is characterized by a broad range of clinical andlaboratory findings like fever, cachexia, hepatosplenomegaly, pancytopenia, hypo albuminuria,anemia, leucopenia, polyclonal hyper gamma globulinemia, or lymph node enlargement. Sodiagnosis and treatment of visceral leishmaniasis is difficult and without appropriate treatment,an estimated 95 % of VL patients will die. Objective: This study aimed to analyze treatment outcomes of patients with visceralleishmaniasis in Konso Zone, Southwest, Ethiopia Methods: Health facility -based, Cross-sectional, retrospective study was conducted among VLpatients who were treated in Konso zone health facilities. Charts of all patients that have beentreated from 2007 to 2022 in the zone that fulfills the inclusion criteria were reviewed. The datawas entered and cleaned using SPSS 20 statistical packages and analysis was carried out usingthe SPSS 20 statistical packages. To identify factors associated with poor treatment outcomes,bivariate, and multivariable logistic regression were carried out. Result: A total of 381 patient's charts were reviewed. The overall level of poor treatmentoutcomes was 6.6%. The presence of sepsis (AOR=3.323%, 95% CI :(1.191-9.273) P=0.022,ascites (AOR=5.919%, 95% CI: (2.269-15.444) P< 0.001, lymphadenopathy (AOR=4.879%,95% CI:(1.875-12.694) P=0.001 and prolonged presentation to health facility of more than onemonth during illness (AOR= 0.366%,95% CI: (0.136-0.985) P=0.047 were found to be theindependent predictors of treatment outcomes. Whereas treatment with the combination of SSG& PM as antileishmanial was inversely related with the poor treatment outcomes (AOR=0.051%, 95% CI: (0.084-0.774) P=0.016. Conclusion and recommendation: Sepsis, ascites, lymphadenopathy, and prolonged duration ofillness at presentation were independent predictors of poor treatment outcomes, whereastreatment with the combination of SSG & PM as antileishmanial was inversely related with thepoor treatment outcomes. Awareness creation in the community on signs and symptoms of VLand scaling up the health-seeking behavior to enhance early presentation to health facilities andtraining of health care providers on complications of VL patients are some of the strategies to bepromoted in improving patient outcomes in VL control programs. Special attention and careshould be given to VL patients with sepsis, ascites, and lymphadenopathy. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6694 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Visceral leishmaniasis treatment outcomes Southwest Ethiopia. | |
| dc.title | Treatment Outcomes of Patients With Visceral Leishmaniasis in Konso Zone, Southern, Ethiopia | |
| dc.type | Thesis |