The Effects of Coriandrum Sativum Seed Extracts on Hyperglycemia, Lipid Profile and Renal Function in Streptozotocin Induced Type - 2 Diabetic Swiss Albino Mice

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Addis Ababa University


Background: Convectional drug treatment for diabetes mellitus carries risks that lead to many adverse effects such weight loss, hypoglycemia and many others. Ethiopia is rich in natural resources and medicinal plants useful in the treatment of diabetes. Aim of the study: To investigate the effect of Coriandrum sativum seed extracts on hyperglycemia, lipid and renal profile in streptozotocin induced diabetic mice. Methods: Thirty six male Swiss albino mice were kept in six different groups for 21 days. Group I served as normal controls; Group II served as diabetic control; Groups III, IV and V were given 300 mg/kg, 400 mg/kg and 500mg/kg of Coriandrum sativum seed extracts (70% ethanol), respectively; and Group VI received 5mg/kg glibenclamide drug. The effect of extracts on hyperglycemia, lipid profile and renal function were tested by chemistry analyzer. Results were analyzed using one way ANOVA at a 5% level of significance. Results: The fasting blood glucose level was significantly (p<0.05) reduced at 400mg/kg and 500mg/kg of Coriandrum sativum extract concentration as compared to the diabetic group. It also reduces total cholesterol, triglyceride, low density lipoprotein, urea and creatinine, and improves high density lipoprotein level and total protein in treated diabetic mice. Conclusion: Reduction in the fasting blood glucose, total cholesterol, triglyceride level, low density lipoprotein, urea, creatinine, and improvement in the high density lipoprotein and total protein by Coriandrum sativum extract indicates that it has anti-hyperglycemic, anti-hyperlipidemia and renal failure restoration effect in streptozotocin induced diabetic mice. Keywords: Diabetes mellitus, Coriandrum sativum, Hyperglycemia, hyperlipidemia, Renal function



Diabetes mellitus; Coriandrum sativum; Hyperglycemia; Hyperlipidemia; Renal function