The Effects of Coriandrum Sativum Seed Extracts on Hyperglycemia, Lipid Profile and Renal Function in Streptozotocin Induced Type - 2 Diabetic Swiss Albino Mice
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Date
2014-05
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Addis Ababa University
Abstract
Background: Convectional drug treatment for diabetes mellitus carries risks that lead to
many adverse effects such weight loss, hypoglycemia and many others. Ethiopia is rich
in natural resources and medicinal plants useful in the treatment of diabetes.
Aim of the study: To investigate the effect of Coriandrum sativum seed extracts on
hyperglycemia, lipid and renal profile in streptozotocin induced diabetic mice.
Methods: Thirty six male Swiss albino mice were kept in six different groups for 21
days. Group I served as normal controls; Group II served as diabetic control; Groups III,
IV and V were given 300 mg/kg, 400 mg/kg and 500mg/kg of Coriandrum sativum seed
extracts (70% ethanol), respectively; and Group VI received 5mg/kg glibenclamide drug.
The effect of extracts on hyperglycemia, lipid profile and renal function were tested by
chemistry analyzer. Results were analyzed using one way ANOVA at a 5% level of
significance.
Results: The fasting blood glucose level was significantly (p<0.05) reduced at 400mg/kg
and 500mg/kg of Coriandrum sativum extract concentration as compared to the diabetic
group. It also reduces total cholesterol, triglyceride, low density lipoprotein, urea and
creatinine, and improves high density lipoprotein level and total protein in treated
diabetic mice.
Conclusion: Reduction in the fasting blood glucose, total cholesterol, triglyceride level,
low density lipoprotein, urea, creatinine, and improvement in the high density lipoprotein
and total protein by Coriandrum sativum extract indicates that it has anti-hyperglycemic,
anti-hyperlipidemia and renal failure restoration effect in streptozotocin induced diabetic
mice.
Keywords: Diabetes mellitus, Coriandrum sativum, Hyperglycemia, hyperlipidemia,
Renal function
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Diabetes mellitus; Coriandrum sativum; Hyperglycemia; Hyperlipidemia; Renal function