Browsing by Author "Workneh Betelehem"

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    Outcome and Associated Factors of Mechanically Ventilated Neonates among Selected Hospitals in Addis Ababa, Ethiopia; Cross -Sectional Multi-Center Study
    (Addis Ababa University, 2024-03) Workneh Betelehem; Shimelis Damte; Tesfaye Melat
    Background: Neonatal mortality has a significant impact on global mortality, morbidity,economic cost, and hospitalization worldwide. Improving neonatal health through innovations inhealthcare, such as mechanical ventilation, is vital for improving the well-being and loweringmortality rates among newborns. The most common indication for MV in NICUs was respiratory distress syndrome. Objective: To assess the outcome and associated factors of mechanically ventilated neonates admitted in three NICUat selected hospitals in Addis Ababa, Ethiopia 2023 Methods: A cross-sectional study was conducted to examine the outcomes and contributing factors for mechanically ventilated neonates admitted to Girum Hospital, Addis Hiwot Hospital,and Myungsung Christian Medical Center (MCM). Three private hospitals were chosen througha simple random sampling method, where a total of 160 mechanically ventilated neonates wereidentified during the study period. A univariate and multivariate binary logistic regression analysis was performed to examine the factors associated mortality of mechanical ventilatedneonates. The results of logistic regression reported as adjusted odds rations (OR) with 95%confidence intervals and p-value < 0.05 are considered statistically significant Results: An analysis of 160 neonates requiring mechanical ventilation that 61.3% were male and63.7% displayed preterm gestational age. The primary reasons for mechanical ventilation (MV)in this study was respiratory distress syndrome (RDS) being the most prevalent at 51.9%,followed by meconium aspiration syndrome (MAS) at 12.5%, and neonatal sepsis at 11.9%. The overall mortality rate of mechanical ventilated neonates was 24.4%. Moving to associated factors requirement of resuscitation(AOR=9.9(1.7, 58.5),p=0.011),extremeprematurity(AOR=61.7(3.3,1150.1),p=0.0006),DIC(AOR=13.1(1.6,104.5),p=0.015),AKI(AOR=13.1(2.24,76.9),p=0.004),MOF(AOR=246.9(14.4,4242.8),p=0.0000)andpulmonaryhemorrhage(AOR=16.7(1.9,145.9), p=0.011)emergedasthemost statistically significant variablesdetermining mortality of neonates on mechanical ventilator Conclusion: The commonest indication for mechanical ventilation in was RDS. Prematurity and disease-related complications were among the preventable factors contributing to mortality.Although the mortality rate of mechanically ventilated neonates is lower compared to similarstudies in low and middle-income countries,.