Browsing by Author "Tsegabirhan K.yohannes"

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    An Experimental Study on the Effect of Crude Extracts of Moringa Stenopetala and Artemisia Absinthium in Trypanosoma Congolense Infected Mice
    (Addis Ababa University, 2011-06-01) Tsegabirhan K.yohannes; Getachew Terefe
    An experimental study was conducted to determine the in vivo anti-trypanosomal effect of water and methanol extracts of the leaves of Moringa stenopetala and aerial parts of Artemisia absinthium against Trypanosoma congolense isolated from Ghibe valley. Thirty-six Swiss white male mice aged between 8 - 12 weeks were divided into six experimental groups of six animals. Water and methanol extracts of the two plants were prepared. T. congolense was isolated from cattle at Ghibe valley (western central Ethiopia) and propagated on mice. All mice groups received I x 105 trypanosomes in 0.2 ml of blood. The plant extracts were given orally to four groups (A. absinthium with water extract, and with methanol extract, M stenopetala with water extract, and with methanol extract) at 400mg/kg body weight for 7 consecutive days. One group remained as distilled water treated control and the other as diminzene aceturate treated control. The effect of the extracts on levels of parasitaemia, body weight, pcv and mice survival was monitored for 25 days. All treatments have significantly reduced the parasitaemia of mice compared to the water treated control (PO.05). There was no significant difference in the reduction of parasitaemia between groups treated with: water extracts of both test plants, methanol extracts of both test plants, water and methanol extracts of A. absinthium, and water and methanol extracts of M stenopetala. The results clearly indicate that groups tTeated with the plant extracts and diminazene aceturate showed significantly lower parasitaemia, higher body weights, pcv and survival rates than the water treated control group (P