Browsing by Author "Teshome Teklu"
Item Assessment of Quality of Service Delivery in Immunization in Western Gojjam, Amhara Region Ethiopia.(Addis Ababa University, 1997-12) Teshome Teklu; Mesfin Kassaye; Nigussie Taffa; Yemane BerhaneMany developed and developing countries have achieved the 1990 uel target. However ,few countries, like Ethiopia, have neither achieved nor maintained it. The coverage in Western Gojjam in 1995\6 for three doses of DPT was below 40%, far below the coverage level expected to bring morbidity and mortality reduction. A cross-sectional health facility based study to assess the quality of immunization service delivery using qualitative and quantitative methods was conducted from March to May 1997 in 10 districts of Western Gojjam zone. All hospitals and health centers in the zone and randomly selected health stations were included in the study . Exit interview, observations of client-provider interaction, document review, inventory of equipment, interview with service providers, and focus group discussions with service providers and mothers were the techniques utilized. Though the geographical access is satisfactory, vaccine shortage, lack of incentives and transport facilities , delayed replacement of needles and syringes were among the structural factors that affect the quality of service delivery , while poor communication, lack of aseptic procedure, lack of proper screening, weak supervision, and absence of EPI target disease surveillance were weakness in the process of service delivery. More than 98 % satisfaction rate was reported by clients of the service duringthe exit interview on the dichotomous scale. But the finding was not consistent with the FGDs and the specific items addressed to assess the satisfaction. Therefore, it is concluded that quality of service delivery in immunization was not satisfactory and hence need improvement to have an effect on coverage and mortality and morbidity reduction targets.Item Blood Clotting Effect in Vitro and Wound Healing Activity in Vivo of Fresh Juice and Ethanolic Extracts of Croton Macrostachyus Leavea in Male Wistar Albino Rats.(Addis Ababa University, 2012-07) Teshome Teklu; Seifu Daniel; Woldyes MihretuBackground: The plant remedies (both single plant and multi-herbal preparations) are used to promote wound healing since ancient times even if the mechanisms of action, toxicity and efficacy of very few of them have been evaluated scientifically. Preparations from plant sources have been traditionally considered effective to stop bleeding and promote wound healing. Juice extract from leaves of Croton macrostachyus has been traditionally used as a local haemostatic medicine to hasten clotting, however, this effect had not been tested in controlled experiments. Aim: There was no scientific evidence justifying the use of Croton macrostachyus, therefore the present study was aimed at evaluation of platelets aggregating and wound healing activity of the plant. Materials and methods: In the present study the Leaves of Croton macrostachyus were studied for procoagulant and wound healing activity by using ethanolic and fresh juice extract. The procoagulant activity was studied by using the effect of extracts on platelets aggregation. Wound healing activity was studied in excision model in rats, wound contraction, period of epithelization, hydroxyproline estimation and histopathological examinations were studied. Results: Ethanolic extract induced significant (P< 0.05) wound healing activity. Conclusion: The ethanolic extract of Croton macrostachyus leaves has procoagulant activity in that it promotes platelets aggregation in vitro that verifies its effect on haemostasis. Moreover, ethanolic extract of the plant leaves promoted wound healing in vivo that could be explained partly by its procoagulant activity and the aqueous juice extract had promoting effect on wound healing that could be explained by the multiple chemical constituents which are of water soluble. Key words: Croton macrostachyus, Platelets aggregation, Procoagulant activity, wound healing, Excision, wound, Hydroxyproline