Browsing by Author "Terefe, Simegne"

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    Magnitude of antibiotic resistant escherichia coli and factors associated with antibiotic resistance among community acquired urinary tract infected patients attending public health centers in Addis Ababa. Ethiopia
    (Addis Ababa Universty, 2018-01) Terefe, Simegne; Deyessa, Negussie (MD, MPH, PhD)
    Background: Urinary tract infections (UTIs) are one of the most common bacterial infections in humans both in the community and hospital settings. It has estimated 150 million cases of UTI worldwide. E. coli is the most common Uro-pathogenic organism. Increasing resistance in E. coli has been reported globally and now considered as one of the major public health problem. Studies in Ethiopia frequently retrieve highest rate of antibiotic resistant in Uro-pathogenic E. coli isolates from hospitals. Community acquired urinary tract infection or uncomplicated (UTI) is mostly treated at primary health care empirically. There is scares data on this issue from health center where uncomplicated UTI is usually treated empirically. Therefore, Knowledge of the magnitude of antibiotic resistant in this organism and assessment of some patient’s activities related OR risk factors which contribute to antibiotic resistant at the community level is important for empirical treatment and future monitoring of antibiotics resistance at community level. Therefore, this study addresses this gap. Objective: To assess magnitude and factors associated with antibiotic resistant in E. coli among community acquired urinary tract infected patients at health center in A.A in the 2017. Methodology: institution based Cross-sectional study was conducted using quantitative methods. Multistage sampling procedure and simple random sampling technique were used to select Sub-cities and health centers. 266 study participants were selected based on their microscopic laboratory Result (urine pus cell count> 10/HPF). Data were collected using interview based questionnaire adopted from different literatures and standardized culture and susceptibility test results record form. Urine sample were collected and analyzed using standard methods. Finally, the collected data were cleaned, entered in to epi-data software and sent to SPSS. Then followed by Analysis of descriptive statistics, bivariate and multivariate respectively Result: About half of participant develops resistance to at least one of the seven antibiotics tested. Ampicillin was found to be the major resisted antibiotic for about three fourth of the seven antibiotics tested for drug sensitivity. Patients who had reported health service facilities were most accessible compared to pharmacies/drug shops; and patients who had taken antibiotics for less than seven days were found to be significantly associated with antibiotics resistance. Conclusion and recommendation: In the study area resistance rates to Ampicillin were high. And Ciprofloxacin was the list resistant and recommended to empirical treatment in the area of study.