Browsing by Author "Temesgen Sheferaw"

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    Assessment of Coagulation Profiles among Chronic Liver Disease Patients Attending Worabe Comprehensive Specialized Hospital, Central Ethiopia Region, Ethiopia
    (Addis Ababa University, 2024-06-18) Temesgen Sheferaw; Aster Tsegaye
    Background: Liver damage from chronic liver disease with substantial changes in the hemostatic system is frequently observed and can develop multiple coagulation abnormalities that disturb the balance between clotting and fibrinolysis. Objective: To assess the coagulation profiles among Chronic liver disease patients attending at Worabe Comprehensive Specialized Hospital from February to May 2024, Central Ethiopia Region, Ethiopia. Methods: A comparative cross-sectional study was conducted among chronic liver disease patients from February to May 2024 at Worabe Comprehensive Specialized Hospital, Central Ethiopia Region. A total of 170 study participants (85 chronic liver disease patients (CLD) and 85 apparently healthy controls) were enrolled using a convenient sampling technique. The socio demographic and clinical data were collected by using a pretested structured questionnaire and from patient’s medical records, respectively. From venous blood samples, the HumaClot Plus coagulation analyzer and the CELL-DYN Ruby automated hematology analyzer were used to determine coagulation parameters and platelet count, respectively. The data was analyzed using SPSS version 27 software. Independent T-test was used to compare coagulation parameters between cases and controls. A P-value less than 0.05 was considered statistically significant. Results: The present study found a Prothrombin time (PT), 15.83 ± 1.49 versus 14.22 ± 0.90 seconds, activated partial thromboplastin time (APTT), 35.99 ± 4.01 versus 33.86 ± 1.33 seconds and international normalization ratio (INR), 1.40 ± 0.18 versus 1.35 ± 0.09 were significantly higher in CLD patients than healthy controls, respectively (P0.05). Conclusion: In this study, CLD patients had significantly increased PT/INR and APTT values, and significantly lower platelet count compared to healthy controls. Therefore, monitoring coagulation profiles and platelet count are suggested for detecting hemorrhagic complications and better management of CLD patients. Key words: Coagulation profiles, Hemostasis, Platelet, Chronic liver disease