Browsing by Author "Tadesse, Etagegen"

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    Assessment of the relationship between serum estradiol, progesterone and lipid profiles levels among breast cancer patients before and after hormonal therapy at Tikur Anbessa Specialized Hospital, Ethiopia
    (Addis Abeba University, 2020-07) Tadesse, Etagegen; Menon, Menakath(PhD); Seifu, Daniel(PhD); Tigeneh, Wondmagegnehu(MD)
    Introduction: Most of breast cancers are induced by abnormal levels of estrogen, progesterone, and changes in lipid profiles. Cancer cells metabolize lipids unlike normal cells and affected by steroid hormones. Estrogen or estradiol controls metabolism of lipids and it regulates rate of progesterone metabolism. Progesterone regulates the effect of estradiol.Tamoxifen and armidex are drugs that block estrogen action on its receptors or decrease estrogen levels. Although, they change progesterone and lipid concentrations in breast cancer patients this may induce adverse effects like hyper /hypo estrogenic properties and lipidimea and other diseases as secondary complications. Thus, assessment of steroid hormones and lipid profile levels are necessary for breast cancer patients, but in Ethiopia, it has not yet been studied and used for treatment. Objective: - To assess the relationship between serum estradiol, progesterone and lipid profiles level among breast cancer patients before and after hormonal therapy at Tikur Anbessa Specialized Hospital. Methods: Cross-sectional study design was used to assess the relationships between serum estradiol, progesterone and lipid profile levels in breast cancer patients before and after hormonal therapy by comparing with healthy controls. Convenient sampling method was used to select 120 participants. Immunochemistry analyzer was used to measure steroid hormone levels and lipids were measured by chemistry analyzer. Data analyzes were done by independent sample t-test, Oneway ANOVA and Pearson‘s correlation coefficient. P-value < 0.05 was taken as statistically significant. Results: In breast cancer patients without medication significantly lower mean serum progesterone, TC and HDL-C levels at (p<0.05) and insignificantly higher estradiol, TG and LDL-C levels at (p>0.05) were observed when compared with healthy controls. Significantly higher mean serum TC, LDL-C, TG, HDL-C levels (p<0.05) and insignificantly higher progesterone and lower estradiol levels were found in breast cancer patients with medication than without medication. Conclusion: Synthesis of lower serum progesterone, HDL-C and higher serum estradiol levels were correlated in breast cancer patients. Armidex and Tamoxifen medications inhibit the levels of steroid hormones and lipid profiles through unclear mode of action. Thus, the change in these hormone and lipid levels may lead to other diseases as secondary complications.