Browsing by Author "Shibre, Gebretsadik (MPH, PhD Candidate)"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Survival Status of Infants with Congenital Anomalies in the Selected Hospitals, Addis Ababa, Ethiopia: A Retrospective Cohort Study
    (Addis Abeba University, 2021-05) Tsegaye, Mahdere; Mekonnen, Wubegzier(M.A., PhD); Shibre, Gebretsadik (MPH, PhD Candidate)
    Background: Congenital malformations are a major health problem and highly contributed to neonatal and child mortality in all Sub-Saharan Africa. However, there are limited and inconsistent pieces of evidence on the survival status of congenital anomalies and their determinants in Ethiopia. Objective: to assess the probability of survivorship and its predictors in the first year of life among babies with congenital anomalies. Methods: A retrospective cohort study design was used among infants with congenital anomalies in Black Lion Specialized Hospital and Zewditu Memorial Hospital in Addis Ababa, registered from 2014 to 2017 which are referred from Addis Ababa region health facilities. Data were collected by reviewing the registration book and interviewing parents by visiting their homes using an electronic data collection tool. Data were analyzed using STATA version 14. The actuarial life table and Kaplan Meier survival curve were analyzed to estimate time to death with a log-rank test to compare survival time between groups. To identify independent predictors Cox-proportional model was carried out and crude and adjusted hazard ratios with 95% Confidence Interval (CI) were used to determine statistical significance. Results: The overall survival probability of infants with congenital anomalies to 7 days, 28 days, and 1-year was 70.3%, 50.0%, and 46.5%. Infant 1-year survival probability with nervous system congenital anomalies had (40.9%), digestive system (42.5%), circulatory system anomalies (43.3%), chromosomal system anomalies (60.0%), musculoskeletal system anomalies (50.0%), respiratory system anomalies (75.0%), and urogenital system (93.3%). The median survival time for those cases that died was 6 days. Survival of male infants and low birth weight infants was significantly poorer survival and those infants who had surgical intervention were significantly better survival. Conclusion: Survival of infants with congenital anomalies to one year is low. Effective interventions are required to focus on nutritional counseling, birth weight, and early surgical intervention to improve the survival probability of infants with congenital anomalies.