Browsing by Author "Mekonnen,Mahlet"

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    Survival Status and Mortality predictors Among Patients with Ventilator Associated Pneumonia admitted to Intensive Care Unit in Addis Ababa Governmental Hospitals: Retrospective Follow-up Study
    (Addis Ababa University, 2024-06) Mekonnen,Mahlet; Getachew,Lemlem (Msc, PhD fellow); Admassu,Wosenyeleh (Msc , Ass.Prof.)
    Background: Ventilator associated Pneumonia causes extended hospital stays for severely ill patients as well as an increase in their financial burden. It is also linked to poor outcomes including morbidity and mortality. Depending on different studies mortality related to VAP ranges from 0- 50% in some studies it can rise to 74%. However, since Ventilator associated Pneumonia mostly affects critically ill patients it is challenging to assess the mortality related to this condition. Objective: To assess Survival Status and predictors of Mortality Among Adult Intubated Intensive Care Unit Patients with Ventilator-Associated Pneumonia in Addis Ababa Governmental Hospitals from January 2021 to April 2024. Methods and materials: Health institution based retrospective cohort study was conducted in purposively selected governmental hospitals among 126 adult intensive care unit patients who developed ventilator associated pneumonia. The data was collected using structured data extraction tool. Mortality probabilities were assessed by Kaplan-Meier analysis method and the log-rank test was used for comparison. The Cox proportional hazard model was used to identify predictors of 90 days mortality among adult VAP patients. For all statistical tests, two-sided P values of less than 0.05 was considered to be statistically significant. Ethical clearance was obtained from ethical clearance board of college of health sciences, Addis Ababa university and ethical clearance committee of each hospitals. Results: A total of 126 VAP patient records were included. The mortality rate of VAP patients was 48.4% (61; 95% CI: 39.7,57.1). Predictors of mortality among VAP patients were use of Vasopressors and inotropes (AHR=2.27), acute kidney injury (AHR=2.12), length of hospital stay (AHR=0.95), length of ICU stay (AHR=0.86), and total days on mechanical ventilator (AHR=1.12). Conclusions: In this study the overall mortality of VAP patients was high. Thus, early detection of VAP in critically ill patients and managing the possible causes of mortality will improve patient outcome.