Browsing by Author "Mebrie,Degayehu"

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    Incidence and determinant factors of Neutropenia among cancer patients receiving chemotherapy at Public Hospitals, Addis Ababa, Ethiopia, 2023
    (Addis Ababa Uinversity, 2023) Mebrie,Degayehu; Boka,Abdissa(Ass. Prof.),Alemu, Tsion( MSc)
    Background: Cancer is one of the most common causes of morbidity and mortality in the world. Around the globe, 19.3 million new cases of cancer were diagnosed in 2020, while about ten million people died from cancer. Patients receiving myelosuppressive chemotherapy for cancer face the risk of developing chemotherapy-induced neutropenia, which puts them at risk for serious consequences like febrile neutropenia. Objectives: This study aimed to assess the incidence and determinant factors of neutropenia among cancer patients receiving chemotherapy at public Hospitals, in Addis Ababa, Ethiopia. Methods; This retrospective follow-up cohort study was carried out at Saint Paul Hospital Millennium Medical college and Tikur Anbessa Specialized Hospital. All eligible cancer patients’ medical records from January 1st, 2020 to December 31st, 2022 were a source population. Computer generated simple random sampling technique was employed to select study participants. Data was collected by using Kobo toolbox software. SPSS version 26 was used for data analysis. Bi-variable logistic regression analysis was carried out to select variables with P-value <0.25. In multivariate analyses the significance of the association was interpreted using an Adjusted Odds Ratio (AOR) by considering a P-value <0.05 with 95% confidence interval. The results were summarized using text, tables and graphs. Result; A response rate of 98.8% was achieved with 348 of the total 352 enrolled participants. The overall incidence of chemotherapy-induced neutropenia was 58.6% [53.6-63.9]. cervical cancer (AOR=0.31(95%CI: 0.096-0.997), normal baseline WBC (AOR =0.492 (95% CI: 0.279- 0.867), and bone metastases (AOR= 2.536(95% CI:1.121-5.737) were significantly associated factors of chemotherapy-induced neutropenia. Conclusion; the overall incidence of neutropenia was high. Baseline WBC, cervical cancer, and bone metastases were significantly associated determinant factors of neutropenia. Throughout the course of chemotherapy, it is critical to make every effort to limit the risk of neutropenia. Determinant factors of neutropenia are multifaceted, and healthcare providers should be familiar with these factors as much as possible