Browsing by Author "Mamo Ephrem"

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Assessment of Metabolic Syndrome Among Government Offices Workers of Some Randomly Selected Offices in Aksum Town, Central Zone, Tigray Region, Ethiopia
    (Addis Abeba University, 2021-08) Mamo Ephrem; Gizawe Solomon ; Gebr Solomon ; Abrar Mohammed
    Background: Metabolic syndrome is a serious public health concern that describes a cluster of disorders and is associated with several health problems. The global prevalence of metabolic syndrome has increased dramatically in the past decade, workplace which directly influence the physical, mental and social well-being of employees are considered important environmental and social determinants for risk of metabolic syndrome. Therefore, biochemical profiling of these population is required. Objectives: This study aimed to assess the association between working environment and metabolic syndrome among workers in Aksum town, central zone, Tigray Region, Ethiopia. Methods: A cross sectional study was conducted from September, 2020 to August, 2021 in Aksum town. A standard questionnaire was used to collect data on socio-demographic variables. Biochemical analysis was done using COBAS C 311 analyzer for the determination of lipid profile, fasting blood glucose and anthropometric measurements. The data were interred into SPSS version 25 and binary logistic regression and linear regression were analyzed to evaluate the association between variables. If P. value ≤ 0.05, it is considered as statistical significance. Result: The findings of this study showed that the magnitude of metabolic syndrome was 16.0% (13% government office workers & 3% Daily laborers). The most common metabolic syndrome components among government office workers reduced high-density lipoprotein-cholesterol were 19%, hypertriglyceridemia was 22% & hypertension was 24%, had significant positively associated with a higher risk of metabolic syndrome (P< 0.05). Hyperglycemia were 18% and abnormality of body mass index was 30% frequently found in government office workers (P >0.05). Government office workers 35% had less vigorous physical activity level, 38% had less type of olive oil used for cooking & 27% had less than 3 serving of fruits and vegetables per week as compared to daily laborers (P< 0.05). Conclusion: In this study, the prevalence of metabolic syndrome was (16%), 13% of government office workers had a higher comparable to 3% of daily laborers. Metabolic syndrome was more common in government office workers, urban population and with advancing age, by hypertension, dyslipidemia and central obesity were the most frequent components of metabolic syndrome. Keywords: Metabolic Syndrome, Lipid Profile, Government Office workers, Metabolic risk factors & Daily laborers.
  • No Thumbnail Available
    Item
    Evaluation of the Acute and sub-Chronic Toxicity of Aqueous Extracts of Moringa Stenopetala Seeds on Kidneys, Liver, and some Blood Parameters of Wistar rats
    (Addis Abeba University, 2021-01) Mamo Ephrem ; Afework Mekbeb
    Traditional medicine is the oldest and culture-based method of the health care system. Among the traditional medicine practices, the use of herbal medicines is the most popular and used by most populations around the globe. M. stenopetala is one of the herbs used as a treatment for various illnesses in different Ethiopian societies. Although there are some data available regarding the various biological activities of the different parts of Moringa plants, that of safety study is scarce, especially relating to the extract of its seeds. The objective of this study was to evaluate the acute and sub-chronic toxic effect of orally administered aqueous extracts of M. stenopetala seeds on gross and histopathology of kidneys and liver, and some blood parameters of Wistar rats. For the acute toxicity study, 15 female rats were randomly divided into five groups with three rats in each group. The experimental groups (Groups I - IV) received a single dose of 300mg/Kg, 2000mg/kg, 3500mg/Kg, and 5000mg/kg of the extract, respectively, while the control group (GroupV) received distilled water orally. For the sub-chronic toxicity study, 24 rats for each sex were randomly divided into four groups, each group comprising of six rats. The rats in the experimental groups (Groups I - III) received 250mg/Kg, 500mg/Kg, and 1000mg/kg oral dose of the extract for 90 days, and the control group (Group IV) received distilled water for a similar duration. In an acute toxicity study, LD50 of the aqueous extract of Mstenopetala seeds was found to be above 5000mg/Kg dose. There were no observed apparent significant differences between the experimental groups and the control group in body weight gain, relative kidneys and liver weight, and gross pathological changes at the end of the 14 days experimental period. In the sub-chronic toxicity study,there was no mortality in all experimental rats of both sexes. Besides, there were no substantial the kidney and liver. Moreover, the light microscopic histopathological examination of sections of the kidney and liver showed no change in the treatment groups as compared with the control group in both sexes. Therefore, this study demonstrated that 90 days oral administration of aqueous M.stenopetala seeds extracts are relatively safe in rats up to 1000mg/Kg dose.