Browsing by Author "Mahelet Tesfaye"

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    The Effects of Covid-19 on the Tourism Events Organized by Great Ethiopian Run
    (Addis Ababa University, 2022-06) Mahelet Tesfaye; Tesfaye Zeleke (PhD)
    The occurrences of the COVID-19 pandemic outbreak have posed a risk that dramatically affects the world and mainly the tourism industry and even in particular the event tourism. The purpose of this thesis was therefore to study the effects of COVID-19 on the GER tourism events in Addis Ababa, Ethiopia. Both primary and secondary data were collected. In the primary data collection, 235 event participants and 30 employees were selected based on availability and completed the questionnaire. The major findings showed that concerning the social effect, more than 61.00% of the respondents were neither handing over their water bottles nor observed others doing the same during the race. Moreover, employees were very much worried, had a negative perception, and would like to minimize their interaction during the event as shown in the reported percentages of 80%, 73.33%, and 73.34% respectively. The outbreak has also brought a reduction in the number of participants from 80,000 to 31,000; resulting in a reduction of overall revenue from 25.65 million ETB in 2019 to 13.959 million ETB in 2020. Irrespective of all these, the GER office had not taken any effective measures other than canceling its events. It was not the case to consult stakeholders for alternative options. Moreover, the GER office has not received substantial support from stakeholders too on strategies to combat the effects of COVID-19. It can be concluded that COVID-19 has brought more economic effects as compared to the social effect as a whole on the organizers. It is recommended that the GER office should have considered virtual events and consulted various stakeholders for getting both professional and financial support.
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    Therapeutic Efficacy of Artemether-Lumefantrine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Metehara Town, Central-East Ethiopia
    (Addis Ababa University, 2024-03) Mahelet Tesfaye; Hassen Mamo; Ashenafi Assefa
    Monitoring and identification of drug-resistant Plasmodium falciparum strains is paramount for the fight against malaria. Close surveillance of the emergence and distribution of artemisinin resistance is recommended to guide policy decisions. The efficacy of national first- and second-line anti-malarial treatments should be monitored at least once every 2 years, as recommended in the WHO standard protocol. In Ethiopia, a three-day regime of AL (artemether 20mg and lumefantrine 120mg in each tablet) is the first-line anti-malarial drug for the treatment of uncomplicated P. falciparum malaria since 2004. The objective of this study was assessing the therapeutic efficacy of AL for the treatment of uncomplicated P. falciparum malaria in Metehara, central-east Ethiopia. The study was conducted at Metehara town health center from November 26, 2020 to March 24, 2021. One-arm prospective evaluation was conducted on the clinical and parasitological responses to directly observed treatment for uncomplicated P. falciparum malaria. During the study regime, 80 patients were screened and 73(50 male and 30 female) participants completed the follow-up and among those 14 patients were <5 age, 25 between the age 5-14 and 34 were >14. The overall cure rate was 100% (73/73; 95% CI: 95.1-100.0) with no early treatment failure, late treatment failure, and late parasitological failure as in Kaplan–Meier analyses all participants completely recovered from parasitemia and fever on day (D) 3; the asexual parasite clearance rate was 100% and clinical symptoms resolved quickly. Gametocyte carriage was reduced from 8.4% on D0 to 1% on D3 and complete clearance was achieved on D7. There was no serious adverse event. In the study location, AL was effective for treating uncomplicated P. falciparum malaria.