Browsing by Author "Legesse Aga"

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    Assesement of Prevalence,Types and Associated Risk Factors of Neutral Tube Defects in Pregnant Women Visiting Health Centers in Addis Abebe.
    (Addis Ababa University, 2019-09) Legesse Aga; Zewdineh Daniel; Gorfu Yocabel
    Introduction:Central nervous system (CNS) defects are the second most common congenital anomalies after congenital heart diseases. Neural tube defects (NTD’s) are amongst the major CNS defects with significant public health burden and long term morbidity and functionalimpairment. Central nervous system (CNS) defects are the second most common congenital anomalies after congenital heart diseases. Neural tube defects (NTD’s) are amongst the majorCNS defects with significant public health burden and long term morbidity and functionalimpairment. Many literatures recommend offering screening for NTDs to all pregnant women.Amniotic fluid AFP (AF-AFP) and amniotic fluid acetylcholinesterease (AChE) are the primary biochemical tests performed on amniotic fluid for detection of open neural tube defects. Theother modality used for screening of these defects is prenatal ultrasound scan. Method:This hospital based cross sectional prospective study tried to show the utility of ultrasound and the prevalence and pattern of occurrence of these defects.About total of 956pregnant mothers who came to the hospital were evaluated with ultrasound scan. Results:We found a total of 6 open NTD’s out of this group. There were 2 anencephaly, 1 ChiariII, 1encephalocele and 1 had both anencephaly and spinabifida. Only 55 % if the respondentstook IFA supplement during pregnancy and of those who took the supplement 43% took it for a maximum of 1 week. Of the parameters we found TCD has a strong correlation with thecalculated mean gestational age. Conclusion and recommendation:The above findings reflect a high incidence of these defects.The low coverage of folic acid supplement as well as poorer socioeconomic factors all wouldcontribute to the observed burden of the disease. Comprehensive screening and preventivestrategies must be designed. Further studies and decisions policy maker level are necessary to improve the current figures.