Browsing by Author "Kassu Afework"

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    Analysis of T Cell Subsets in HIV-L Infected and un Infected Ethiopians on the Basis of Various Differentiation and Activation Markers in the Context of Intestinal Parasitic Infections
    (Addis Ababa Universty, 2001-06) Kassu Afework; Petros Beyene (PhD)
    The present study assessed whether expansion of a specific sub-population of CD8+ T cells is responsible for variations in CD8+ T cell counts; and also investigated the effect of incident intestinal parasitic infection and treatment on the profile of various differentiation and activation markers on CD4+ and CD8+ T cells from HIV-1 infected and uninfected adult Ethiopians (n=150). The pattern of CD8+ T cell population in whole blood samples of 86 subjects (60 HIV negative and 26 HIY positive) from Akaki and Wonji were analysed. The effect of incident intestinal parasites and their treatment was studied on cryo preserved PBMCs of 64 subjects (41 HIY- and 23 HIV+). In both cases, the samples were stained with antibodies to various T cell differentiation and activation markers and naiVe, memory, effector, memory/effector, activated and resting CD4+ and CD8+ T cell subsets were quantified by triple colour FACScan. Significantly higher (P