Browsing by Author "Henock Hailu,"

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    The Magnitude and Associated Risk factors of Lipodystrophy among Type 1 DM Children and Adolescents on follow up at Black Lion Hospital Pediatric Endocrinology Unit
    (Addis Ababa University, 2025-04-04) Henock Hailu,; Sewagegn Yeshiwas
    Type 1 diabetes(T1DM) is chronic autoimmune disease that results from the progressive destruction of pancreatic beta cells, insulin deprivation and therefore, the patients require insulin therapy throughout their lives. Lipodystrophy is a common side effect of insulin use in T1DM patients, characterized by changes in distribution and volume of subcutaneous fat stores. Lipodystrophy therefore can also be lipohypertrophy experienced when fat starts accumulated at the areas where one applies insulin and lipoatrophy which is actually experienced when one loses his or her fat tissue. Severe clinical consequences may include insulin resistance in case of Lipodystrophy, episodes of poor glycemic control and worsened diabetes complications. Research recognizes the lipodystrophy’s prevalence among T1DM patients to be 28-66%. Potential risk factors associated with lipodystrophy include duration of the diabetes, insulin use and incorrect method of insulin administration. Nevertheless, lipodystrophy epidemiology and risk factors in T1DM individuals can differ depending on geographical location and some settings.