Browsing by Author "Gulilat Addis"

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    Dosimetrice Valuation of Palliative Hypo Fractionated Radiotherapy and its Effect on Clinical Outcome Inpatients with Vertebral Bone Metastasis Treated at Tikur Anbessa Specialized Hospital,Oncology Center, Addis Ababa,Ethiopia:An Institution -Based Retrospective Cross-Sectional Study.
    (Addis Ababa University, 2023-12) Gulilat Addis; Dandena Yonas; Belay Eskadmas
    The purpose of this tudywastoevaluatedosimetri cparametersofthree-di conformalradiotherapy(3D-CRT)andanal yzeitseffectoncl controlandtoxi city.Assessmentofthetreatmentpl mensional inicaloutcomesincl udingpain ansinthestudywascarriedoutbasedon reporteddosimetri cparameters,whereaspatientreportedpai nscoreandtoxicitywereusedfor assessingresponse. Methods:Aninstituti on-basedretrospecti s.Stati vecrosssectionalstudywasconductedfromJune Sept2023. ThedatawascollectedusingKobotoolboxandwasexportedtoSPSSversion26 foranalysi sticaltestsandanal ysiswasconducted.Variabl signifi cancep-value110%,thelargestbeing117%.Acutetoxicity wasseenin36(37.1%)ofpatientsfromthese23.4%wassevere.Theconformityindexwas foundtobeb/n1-2in97%ofthecases.Incontrary,homogeneityindexwasdifferentfromzero in100%ofthecases.OfpatientswhosemeandosewasmeasuredlungDmeanwas>13GYin 2(4.4%)pati entswhilekidneyDmeanwas>18GY(EQD2)in1(1.5%).Thereasonforpoor coverage,hi ghDmaxdoseandhighmeandoseforOARsmaybethewrongassumptionof consideri ngallpall iati vepatientsasshorttermsurvi vors,andadvancedpresentati diffusevertebralmetastasi sresulti ngdiffi Conclusion:Adeviati cultyonplanoptimizati onwith on. onfromrecommendedvaluewasseeninD95%,Dmax,DmeanandHI.This suggestsasthereshouldbemoreefforttooptimizepl ansandstrictl yevaluatetheDVH.Lack ofsignifi cancerelati ononmultivariateanal ysismaybeduetosamplesizeandthosecasesthat hadtoxicitymighthavemissedduetoearlydeat