Browsing by Author "Guadu Atakilt"

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    Virological Response and Tolerability of Dolutegravir based Regime for Children Living with Hiv and its Associated Factors.
    (Addis Ababa University, 2025-04-24) Guadu Atakilt; Workeabeba Abebe
    Background: The World Health Organization advised using integrase strand transfer inhibitors and strong ART medications, particularly HAART, as soon as the diagnosis was established. Due to its low side effects, excellent viral suppression, and superior gentic barrier against ART medication resistance, DTG is preferred over other ART drug regimens. Weight loss, hepatotoxicity, elevated blood sugar, and sleep disturbance are some of the side effects associated with DTG-based regimens, but other benefits include low side effects, high viral suppression, and a better genetic barrier against ART medication resistance. DTG is used as first- and second-line ART regimens, and early initiative HAART plays a significant role in lowering morbidity and mortality. Objectives: To evaluate children with HIV's virological response and side effects related to a DTG based regimen Methods: This study was conducted in the pediatric infectious disease specialty hospital Tikur Anbessa using a retrospective cross-sectional study methodology. SPSS 26 was used to enter the data for any ensuing descriptive and analytical statistics. In terms of statistics, a p-value of less than 0.05 was considered to indicate a significant.. Result We included 218 children living with HIV on a DTG-based regimen, and after 6–12 months, the prevalence of viral suppression was 92.7%. However, only 6.4% of study participants started a DTG based regimen with reported side effects, such as gastrointestinal symptoms like nausea 11 (5%), and sleep disturbance 3 (1.3%), after taking it within 24 hours. There were no serious side effects, and the side effects were insufficient to cause them to change their ART regimen. In this study, the viral suppression rate was 71% (95% CI;.316,26.2, AOR 1.593), p-value<.0.016. ART can reduce viral load as soon as it is started, and the adherence to the regimen was 96% (95% CI;.678,51, AOR 1.912), p-value <.025. Poor adherence was linked to high viral load. conclusion According to this study, children with HIV who are on a DTG-based regimen have good viral suppression, good tolerability, and a low incidence of side events.