Browsing by Author "Gebremeskel, Kibrom"

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    Assessment of Malnutrition Using Biochemical Markers among Female Breast Cancer Patients Attending Tikur Anbessa Specialized Hospital, Ethiopia
    (Addis Ababa University, 2017-06) Gebremeskel, Kibrom; Genet, Solomon (PhD)
    Introduction: Breast cancer is the most common cancer worldwide. Malnutrition occurs frequently in cancer patients. Malnourished cancer patient responds poorly to therapeutic interventions, such as chemotherapy, radiotherapy and surgery with increased morbidity and mortality. Objective: The aim of the present study was to evaluate malnutrition in breast cancer patients through biochemical markers at Tikur Anbessa Specialized Hospital, Ethiopia. Materials and methods: Hospital based cross-sectional study was conducted in 50 breast cancer patients and 50 healthy individuals from January to April 2017 at Tikur Anbessa Specialized Hospital, Ethiopia. The required amount of blood was withdrawn from both group by well trained nurses in the hospital and serum stored at -800c refrigerator until analysis. Data were collected on socio demographic factors, biochemical, anthropometric and hematological parameter. Result: The mean age of the study and control group was 43.06 year. Comparison of mean between study and control group shows 3.89 ± 0.04 g/dl and 4.34 ± 0.17g/dl for albumin, 3.92 ± 0.08 g/dl and 3.35 ± 0.04 g/dl for globulin, 1.73 x 103 ± 0.29 cells / mm3 and 2.35 x 103 ± 1.12 cells /mm 3 for total lymphocyte count, 0.72 ± 0.03 mg/l and 0.96 ± 0.03 mg/l for creatinine, 25.19 ± 1.22 mg/l and 21.62 ± 1.01 mg/l for urea for study and control group respectively. All the above mean values show statistically significant difference between study and control groups with p value < 0.05. There were no statistically significant difference mean value levels of total protein and body mass index in our study. Prevalence of malnutrition assessed through albumin was 32%, TLC 46% and BMI 36%. Pearson correlation analysis revealed positive correlation between globulin and total protein level (r = 0.84, P < 0 .0001) and negative correlation between albumin and globulin level (r = -0.48, p < 0.0001) in the breast cancer patients. Albumin positively correlated with TLC (r = 0.51, p= 0.03) in the breast cancer patients. Conclusion: The present study revealed serum albumin, globulin, creatinine, urea level were reliable biochemical markers combined with TLC for assessment of malnutrition in breast cancer patients. Key words: breast cancer, Malnutrition, Albumin, Globulin, creatinine and total lymphocyte Count